The Relationship between Revascularisation and Osteogenesis in Fresh or Demineralised Bone Grafts
| Autor: | Else Marie Pinholt, Eirik Solheim, Trine Berg Larsen, Ove Talsnes, Ole J. Kirkeby |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Bone Demineralization Technique Bone Transplantation Chemistry Neovascularization Physiologic Bone and Bones Rats Surgery Microsphere Demineralization Transplantation Isogeneic Bone Density Osteogenesis Rats Inbred Lew Iliac bone medicine Animals Bone formation Linear correlation |
| Zdroj: | European Surgical Research. 33:42-46 |
| ISSN: | 1421-9921 0014-312X |
| DOI: | 10.1159/000049692 |
| Popis: | Bone formation generally depends on adequate blood flow. Failure of bone grafts has been attributed to delayed revascularisation of the graft. We compared the relationship between revascularisation and osteogenesis, evaluated as entrapment of 141Ce-labelled microspheres and uptake of 85Sr, respectively, in fresh or demineralised syngeneic bone grafts 3 weeks after heterotopic implantation in rats. Whereas a moderately high linear correlation between 85Sr and 141Ce radioactivity was found both in the (intact) host iliac bone (r = 0.75, p = 0.0001) and implanted fresh syngeneic grafts (r = 0.50, p = 0.001), no correlation could be demonstrated in demineralised grafts (r = 0.09, p = 0.6). The results may indicate differences in the mechanisms of vascularisation and osteogenesis in the grafts used fresh or after demineralization but are, at present, difficult to fully explain. |
| Databáze: | OpenAIRE |
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