Polyethylene glycol versus lactulose in the treatment of hepatic encephalopathy: a systematic review and meta-analysis
| Autor: | Judie Hoilat, Savio John, Talal Adhami, Mohamad F. Ayas, Gilles J. Hoilat, Seren Durer, Ceren Durer, Ahmed Abu-Zaid |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Cirrhosis Polyethylene glycol RC799-869 Cochrane Library Gastroenterology Mean difference Polyethylene Glycols chemistry.chemical_compound Lactulose Internal medicine PEG ratio medicine Humans Hepatic encephalopathy Hepatology business.industry cirrhosis Diseases of the digestive system. Gastroenterology medicine.disease chemistry Hepatic Encephalopathy Meta-analysis lactulose business medicine.drug |
| Zdroj: | BMJ Open Gastroenterology, Vol 8, Iss 1 (2021) BMJ Open Gastroenterology |
| ISSN: | 2054-4774 |
| Popis: | BackgroundHepatic encephalopathy (HE) is defined as brain dysfunction that occurs because of acute liver failure or liver cirrhosis and is associated with significant morbidity and mortality. Lactulose is the standard of care till this date; however, polyethylene glycol (PEG) has gained the attention of multiple investigators.MethodsWe screened five databases namely PubMed, Scopus, Web of Science, Cochrane Library and Embase from inception to 10 February 2021. Dichotomous and continuous data were analysed using the Mantel-Haenszel and inverse variance methods, respectively, which yielded a meta-analysis comparing PEG versus lactulose in the treatment of HE.ResultsFour trials with 229 patients were included. Compared with lactulose, the pooled effect size demonstrated a significantly lower average HE Scoring Algorithm (HESA) Score at 24 hours (Mean difference (MD)=−0.68, 95% CI (−1.05 to –0.31), pConclusionPEG leads to a higher drop in the HESA Score and thus leads to a faster resolution of HE compared with lactulose. |
| Databáze: | OpenAIRE |
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