Phosphodiesterase type 5 inhibitor attenuates chronic ischemia‐induced prostatic hyperplasia in a rat model
| Autor: | Yoshihide Kawasaki, Naoki Kawamorita, Akihiro Ito, Juntaro Koyama, Yoichi Arai, Shinji Fujii, Hideaki Izumi, Natsuho Hayashi, Takuro Goto, Shuichi Shimada, Takuma Sato, Koji Mitsuzuka, Shinichi Yamashita |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Urology Prostatic Hyperplasia Ischemia Femoral artery Tadalafil Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Prostate medicine.artery Animals Medicine business.industry Arteriosclerosis Phosphodiesterase 5 Inhibitors Hyperplasia medicine.disease Common iliac artery Rats Disease Models Animal 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis cGMP-specific phosphodiesterase type 5 business medicine.drug |
| Zdroj: | The Prostate. 79:536-543 |
| ISSN: | 1097-0045 0270-4137 |
| DOI: | 10.1002/pros.23759 |
| Popis: | Background Many elderly men suffer from benign prostatic hyperplasia (BPH). Recently, chronic ischemia in the prostate has been suggested to be related to BPH. Thus, the impact of chronic ischemia on the development of prostatic hyperplasia and the efficacy of phosphodiesterase type 5 (PDE5) inhibitor for hyperplasia were evaluated in a rat model with chronic ischemia induced by local atherosclerosis. Methods Eighteen male Sprague-Dawley rats were divided into three groups: sham operation, regular diet, placebo (SRP); arterial endothelial injury, high cholesterol diet, placebo (AHP); or arterial endothelial injury, high cholesterol diet, and tadalafil as a PDE5 inhibitor (AHT). The endothelial injury in the common iliac arteries was performed using a 2-Fr Fogarty arterial embolectomy catheter through an incision in the femoral artery into the common iliac artery. Diet and oral drugs were administrated for 8 weeks after surgery. At 8 weeks, blood flow to the ventral prostate (VP) was measured using laser speckle blood flow analysis, and the VP was histologically evaluated. Results In the AHP group, prostatic blood flow was reduced, and mean VP weight and the interstitial area were significantly enlarged compared with the SRP group. In the AHT group, tadalafil administration obviously ameliorated the reduction of prostatic blood flow relative to the AHP group. Importantly, mean VP weight and the morphological changes in the AHT group were significantly smaller than those in the AHP group. Conclusions Enlargement of the VP resulted from chronic ischemia induced by local arteriosclerosis. Also, administration of tadalafil attenuated VP enlargement. Chronic ischemia in the prostate might thus contribute to the development of BPH, and PDE5 inhibitors might provide an innovative approach to preventing BPH. |
| Databáze: | OpenAIRE |
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