Effect of hyperhomocysteinemia on rat cardiac sarcoplasmic reticulum

Autor:	Zuzana Tatarkova, Maria Bencurova, Jan Lehotsky, Peter Racay, Monika Kmetova Sivonova, Dusan Dobrota, Peter Kaplan
Rok vydání:	2022
Předmět:	Myocardium Calcium-Binding Proteins Clinical Biochemistry Hyperhomocysteinemia Heart Cell Biology General Medicine Myocardial Contraction Rats Sarcoplasmic Reticulum Calcium-Transporting ATPases Sarcoplasmic Reticulum Animals Calsequestrin Calcium Molecular Biology
Zdroj:	Molecular and Cellular Biochemistry. 477:1621-1628
ISSN:	1573-4919 0300-8177
Popis:	Increased concentration of plasma homocysteine (Hcy) is an independent risk factor of cardiovascular disease, yet the mechanism by which hyperhomocysteinemia (HHcy) causes cardiac dysfunction is largely unknown. The aim of present study was to investigate the contribution of sarcoplasmic reticulum to impaired cardiac contractile function in HHCy. HHcy-induced by subcutaneous injection of Hcy (0.45 μmol/g of body weight) twice a day for a period of 2 weeks resulted in significant decrease in developed left ventricular pressure and maximum rate of ventricular relaxation. Our results show that abundances of SR Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e752593406e97c99f9f7fdac574301cb https://doi.org/10.1007/s11010-022-04399-z Zobrazit plný text záznamu Full text from SpringerLink