A novel radiolabeled graft polymer: Investigation of the radiopharmaceutical potential using Albino Wistar rats
| Autor: | Buket Ateş, Sinan Akgöl, Fikriye Gül Gümüşer, Uğur Avcıbaşı, Volkan Tekin, Kevser Kusat Ol, Perihan Ünak, Süleyman Gülcemal |
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| Přispěvatelé: | Department of Chemistry, Manisa Celal Bayar University, Faculty of Art and Science, Manisa, 45140, Turkey, Institute of Nuclear Sciences, Ege University, Department of Nuclear Applications, İzmir, 35100, Turkey, Department of Nuclear Medicine, Manisa Celal Bayar University, School of Medicine, Manisa, 45030, Turkey, Department of Chemistry, Ege University, Faculty of Science, Izmir, 35100, Turkey, Turkish Health of Ministry, Turkish Medicines and Medical Devices Agency, Ankara, Turkey, Department of Biochemistry, Faculty of Science, Ege University, İzmir, 35100, Turkey, Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Biodistribution Polymers Thin layer 010403 inorganic & nuclear chemistry Scintigraphy 01 natural sciences 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound Nanoparticle 0302 clinical medicine Drug Stability medicine Animals Tissue Distribution Rats Wistar Magnetite Nanoparticles Polyhydroxyethyl Methacrylate Radiation Chromatography medicine.diagnostic_test Chemistry Stomach HEMA L-lysine Organotechnetium Compounds Grafted polymer Tc-99m Rats 0104 chemical sciences High uptake medicine.anatomical_structure Graft polymer Lipophilicity Microscopy Electron Scanning Female Radiopharmaceuticals |
| Popis: | UNAK, PERIHAN/0000-0002-5464-2987; Gulcemal, Suleyman/0000-0003-2738-3219 WOS: 000498291900045 PubMed: 31470192 Fe3O4 magnetic graft-Lys-poly(HEMA) was synthesized, labeled with Tc-99m for the first time and its radiopharmaceutical potential was investigated using animal models in this study. Quality control procedures were carried out using thin layer radiochromatography. the labeling yield of radiolabeled polymer was found to be about 100%. Then, stability and lipophilicity were determined. the lipophilicity of Tc-99m labeled Fe3O4 graft-Lys-poly(HEMA) was found to be 3.77. the serum stability experiments demonstrated that approximately 100% of radiolabeled polymer existed as an intact complex in the rat serum within 240 min. Biodistribution of radiolabeled magnetic graft-Lys-poly(HEMA) was performed on female Albino Wistar rats by scintigraphy and biodistribution studies. High uptake was seen in the stomach, the pancreas, brain, ovarian, intestines and the breast. Manisa Celal Bayar University Coordination Unit of Scientific Research Projects (BAP) [2017-016] The authors are thankful for the financial support from the Manisa Celal Bayar University Coordination Unit of Scientific Research Projects (BAP) (Project number: 2017-016). |
| Databáze: | OpenAIRE |
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