Presynaptic Group II mGluR Inhibition of Short-Term Depression in the Medial Perforant Path of the Dentate Gyrus In Vitro
| Autor: | Roger Anwyl, Anthony M. Rush, John Kilbride, Michael J. Rowan |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Cyclopropanes
Male Agonist Physiology medicine.drug_class Perforant Pathway Glycine Hippocampus Stimulation In Vitro Techniques Receptors Metabotropic Glutamate Synaptic Transmission Bridged Bicyclo Compounds Excitatory Amino Acid Agonists medicine Animals Rats Wistar Chemistry musculoskeletal neural and ocular physiology General Neuroscience Dentate gyrus Excitatory Postsynaptic Potentials Neural Inhibition Perforant path Electric Stimulation In vitro Rats medicine.anatomical_structure nervous system Metabotropic glutamate receptor Dentate Gyrus Excitatory postsynaptic potential Anticonvulsants Neuroscience |
| Zdroj: | Journal of Neurophysiology. 85:2509-2515 |
| ISSN: | 1522-1598 0022-3077 |
| DOI: | 10.1152/jn.2001.85.6.2509 |
| Popis: | Inhibition of short-term plasticity by activation of presynaptic group II metabotropic glutamate receptors (group II mGluR) was investigated in the medial perforant path of the dentate gyrus in the hippocampus in vitro. Brief trains of stimulation (10 stimuli at 1–200 Hz) evoked short-term depression of field excitatory postsynaptic potentials (EPSPs). The steady-state level of depression, measured after 10 stimuli, was frequency dependent, increasing between 1 and 200 Hz. Activation of group II mGluR by the selective agonist LY354740 did not alter short-term depression evoked by frequencies up to 10 Hz, but did inhibit short-term depression evoked at higher frequencies in a frequency- and concentration-dependent manner. The time-averaged postsynaptic response (EPSP per unit time) was found to increase linearly with frequency up to ∼20 Hz. At higher frequencies, the response plateaued, thereby becoming independent of frequency. Frequencies above this were differentiated only during the transient postsynaptic response that accompanies changes in firing rates. Activation of presynaptically located group II mGluR increased the frequency at which the EPSP per unit time plateaued up to 30–50 Hz. |
| Databáze: | OpenAIRE |
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