L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential
| Autor: | James S. Metcalf, Paul Alan Cox, S. A. Banack, Rachael A. Dunlop, James T. Powell |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Central nervous system L serine Biology Toxicology Neuroprotection 03 medical and health sciences 0302 clinical medicine medicine Serine Animals Humans chemistry.chemical_classification General Neuroscience Neurodegeneration medicine.disease Amino acid 030104 developmental biology medicine.anatomical_structure Neuroprotective Agents Biochemistry chemistry Metabolic enzymes Glycine Nervous System Diseases 030217 neurology & neurosurgery Cysteine |
| Zdroj: | Neurotoxicity research. 33(1) |
| ISSN: | 1476-3524 |
| Popis: | In human neuroblastoma cell cultures, non-human primates and human beings, L-serine is neuroprotective, acting through a variety of biochemical and molecular mechanisms. Although L-serine is generally classified as a non-essential amino acid, it is probably more appropriate to term it as a "conditional non-essential amino acid" since, under certain circumstances, vertebrates cannot synthesize it in sufficient quantities to meet necessary cellular demands. L-serine is biosynthesized in the mammalian central nervous system from 3-phosphoglycerate and serves as a precursor for the synthesis of the amino acids glycine and cysteine. Physiologically, it has a variety of roles, perhaps most importantly as a phosphorylation site in proteins. Mutations in the metabolic enzymes that synthesize L-serine have been implicated in various human diseases. Dosing of animals with L-serine and human clinical trials investigating the therapeutic effects of L-serine support the FDA's determination that L-serine is generally regarded as safe (GRAS); it also appears to be neuroprotective. We here consider the role of L-serine in neurological disorders and its potential as a therapeutic agent. |
| Databáze: | OpenAIRE |
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