Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats
Autor: | D. S. Ragaeva, Eugeny Brusentsev, Olga M. Petrova, Anna A. Akopyan, Maria A. Tikhonova, T. N. Igonina, Irina N. Rozkova, Yegor V Antonov, Sergey Ya. Amstislavsky, Tamara G. Amstislavskaya |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Offspring Neurogenesis Rat model Blood Pressure Early pregnancy factor Hippocampal formation Hippocampus Internal medicine Internal Medicine medicine Animals Pregnancy Behavior Animal biology business.industry Brain-Derived Neurotrophic Factor Obstetrics and Gynecology Recognition Psychology Embryo Transfer medicine.disease Phenotype Embryo transfer Rats Endocrinology Blood pressure Hypertension biology.protein Female business |
Zdroj: | Hypertension in Pregnancy. 39:283-294 |
ISSN: | 1525-6065 1064-1955 |
Popis: | The study investigates how surgery during pregnancy, i.e., sham operation associated with embryo transfer, affects hypertensive phenotype in ISIAH rats genetically predisposed to hypertension. ISIAH rats born after maternal surgery at fourth day of pregnancy were compared with naturally conceived controls. Surgery during pregnancy in ISIAH rats caused acceleration of neurodevelopment in young offspring, as well as aggravating hypertension, suppressing exploratory activity, reducing hippocampal BDNF expression, and compensatory increasing of hippocampal neuronal density in adult ISIAH offspring. Maternal surgery during early pregnancy caused alterations in offspring phenotype in hypertensive ISIAH rat model. |
Databáze: | OpenAIRE |
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