Effectiveness of interferon-alpha therapy in chronic hepatitis C is associated with the amount of interferon-alpha receptor mRNA in the liver
| Autor: | Shuichi Satoh, Sachiko Nagasawa, Shiro Fukumoto, Nobuyuki Moriyama, Shunji Ishihara, Shuji Akagi, Shino Sakai, Yoshinori Kushiyama, Tatsuya Miyake, Makoto Watanabe, Ryo Fukuda, Norihisa Ishimura, Misa Niigaki |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_treatment Alpha interferon Hepacivirus Receptor Interferon alpha-beta Pharmacology Interferon alpha-2 Antiviral Agents Injections Intramuscular Polymerase Chain Reaction Interferon Fibrosis Predictive Value of Tests Medicine Humans RNA Messenger Interferon alfa DNA Primers Receptors Interferon Messenger RNA Hepatology Dose-Response Relationship Drug business.industry Interferon-alpha Immunotherapy Middle Aged medicine.disease Hepatitis C Actins Recombinant Proteins Reverse transcription polymerase chain reaction Cytokine Treatment Outcome Liver Immunology Chronic Disease RNA Viral Female business medicine.drug Follow-Up Studies |
| Zdroj: | Journal of hepatology. 26(3) |
| ISSN: | 0168-8278 |
| Popis: | This study aimed to investigate the relationship between interferon-alpha receptor mRNA in the liver and the response to interferon therapy in chronic hepatitis C.Interferon-alpha receptor mRNA was quantified by reverse transcription polymerase chain reaction using liver biopsies from 40 patients, comprising 20 responders and 20 non-responders to subsequent interferon therapy.The amount of interferon-alpha receptor mRNA was significantly larger in interferon-responders (0.72+/-0.12) than non-responders (0.26+/-0.08) (p0.01). Regardless of the response to interferon, histological activity index scores and the amount of HCV-RNA showed significant inverse correlation to the amount of interferon-alpha receptor mRNA, whereas the HCV-RNA genotype was not associated with the amount of interferon-alpha receptor mRNA. Logistic analysis and multiple regression analysis showed that the amount of interferon-alpha receptor mRNA was significantly associated with the efficacy of interferon (p=0.0275), but not with fibrosis of the liver (p= 0.2726).Our results suggest that the amount of interferon-alpha receptor mRNA is an important factor determining the response to interferon, and may be a new predictor of interferon response in chronic hepatitis C. |
| Databáze: | OpenAIRE |
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