Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by Affecting Leptin Expression on Offspring's Early and Late Period in Life Depending on Gender
Autor: | Nazan Uysal, Cetin Pekcetin, Ferihan Cetin, Ayfer Dayi, Ilkay Aksu, Seda Ozbal, Celal Gençoğlu, Sinem Agilkaya, Sultan Cingoz, Berkant Muammer Kayatekin, Kazim Tugyan |
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Rok vydání: | 2012 |
Předmět: |
Male
medicine.medical_specialty Article Subject Cell Survival Offspring Neurogenesis lcsh:Medicine Adipose tissue Biology lcsh:Technology Statistics Nonparametric General Biochemistry Genetics and Molecular Biology Sex Factors Memory Pregnancy Physical Conditioning Animal Internal medicine medicine Animals Aerobic exercise Rats Wistar Maze Learning lcsh:Science CA1 Region Hippocampal General Environmental Science Neurons Neuronal Plasticity Thigmotaxis Leptin receptor lcsh:T Dentate gyrus Leptin lcsh:R Age Factors General Medicine medicine.disease CA3 Region Hippocampal Rats Endocrinology Dentate Gyrus Receptors Leptin Female lcsh:Q Research Article |
Zdroj: | The Scientific World Journal, Vol 2012 (2012) The Scientific World Journal |
ISSN: | 1537-744X |
Popis: | Maternal exercise during pregnancy has been suggested to exert beneficial effects on brain functions of the offspring. Leptin is an adipocytokine which is secreted from adipose tissues and has positive effects on learning, memory, and synaptic plasticity. In this study, pregnant rats were moderately exercised and we observed the effects of this aerobic exercise on their prepubertal and adult offsprings' spatial learning, hippocampal neurogenesis, and expression of leptin. All the pups whose mothers exercised during pregnancy learned the platform earlier and spent longer time in the target quadrant. Their thigmotaxis times were shorter than those measured in the control group. It is shown that hippocampal CA1, CA3 neuron numbers increased in both prepubertal and adult pups, in addition that GD neuron numbers increased in adult pups. Leptin receptor expression significantly increased in the prepubertal male, adult male, and adult female pups. In our study, maternal running during pregnancy resulted in significant increase in the expression of leptin receptor but not in prepubertal female pups, enhanced hippocampal cell survival, and improved learning memory capability in prepubertal and adult rat pups, as compared to the control group. In conclusion, maternal exercise during pregnancy may regulate spatial plasticity in the hippocampus of the offspring by increasing the expression of leptin. |
Databáze: | OpenAIRE |
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