High Intratumoral Accumulation of Stealth Liposomal Doxorubicin in Sarcomas: Rationale for Combination with Radiotherapy
| Autor: | Stylianos Kakolyris, Georgoulias, Alexandra Giatromanolaki, Archimandritis S, Velidaki A, Koukouraki S, Karkavitsas Nn, Michael I. Koukourakis |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Oncology Stealth Liposomal Doxorubicin medicine.medical_specialty medicine.medical_treatment Locally advanced Antineoplastic Agents Bone Neoplasms Radioresistance Internal medicine medicine Humans Tissue Distribution Radiology Nuclear Medicine and imaging Doxorubicin Infusions Intravenous Aged Drug Carriers business.industry Sarcoma Hematology General Medicine Middle Aged medicine.disease Combined Modality Therapy Radiation therapy Regimen Total dose Liposomes Female business medicine.drug |
| Zdroj: | Acta Oncologica. 39:207-211 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.1080/028418600430789 |
| Popis: | Sarcomas are radioresistant tumors, the only curative therapy being radical surgical resection. Stealth liposomal doxorubicin (Caelyx) is a novel drug formulation that allows prolonged circulation and high intratumoral concentration. This study investigates the concurrent use of radiotherapy with Caelyx in a cohort of 7 patients with locally advanced or recurrent sarcoma. Radiotherapy was given as a standard fractionation regimen to a total dose of 70 Gy. Caelyx was given as a 30-min infusion at a dose of 25 mg/m2 every 2 weeks. Scintigraphic imaging with Caelyx-99mTc-DTPA showed an increased (2.8 +/- 0.9 times higher) intratumoral drug accumulation compared to the surrounding healthy tissue. The regimen was well tolerated without any severe hematological or systemic toxicity. 'In field' radiation toxicity was not increased. Complete response was observed in 4/7 cases. It is concluded that combined chemo-radiotherapy with stealth liposomal doxorubicin for locally advanced sarcomas is feasible and promising, the benefit expected from the unique ability of the stealth liposomes to accumulate selectively in the tumoral tissue. |
| Databáze: | OpenAIRE |
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