Cardiac output is not a significant source of low frequency mean arterial pressure variability
| Autor: | Xiaoxiao Chen, Donal S. O'Leary, Giuseppe Baselli, Robert L. Hammond, Federico Aletti, Ramakrishna Mukkamala, Javier A. Sala-Mercado |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Mean arterial pressure Cardiac output Physiology Rest Peripheral resistance 0206 medical engineering Biomedical Engineering Biophysics 02 engineering and technology 030204 cardiovascular system & hematology Low frequency Baroreflex Models Biological Article 03 medical and health sciences Dogs 0302 clinical medicine Nuclear magnetic resonance Control theory Physiology (medical) Respiration Animals Arterial Pressure Cardiac Output Physics 020601 biomedical engineering Predictive value Female |
| Zdroj: | Physiological Measurement. 34:1207-1216 |
| ISSN: | 1361-6579 0967-3334 |
| DOI: | 10.1088/0967-3334/34/9/1207 |
| Popis: | Spontaneous mean arterial pressure (MAP) variability may be mainly due to fluctuations in cardiac output (CO) and total peripheral resistance (TPR). While high frequency (HF ∼ 0.25 Hz) oscillations in MAP are ultimately driven by respiration, the source of low frequency (LF ∼ 0.1 Hz) fluctuations has not been fully elucidated. It is known that CO buffers these oscillations, but there is no evidence on its potential role in also generating them. The main goal was to determine whether CO is a source of LF variability in MAP. Six dogs were chronically instrumented to obtain beat-to-beat measurements of CO and MAP while the dogs were fully awake and at rest. A causal dynamic model was identified to relate the fluctuations in CO to MAP. The model was then used to predict the MAP fluctuations from the CO fluctuations. The CO fluctuations were able to predict about 70% of the MAP oscillations in the HF band but showed no predictive value in the LF band. Hence, respiration induces CO fluctuations in the HF band that, in turn, cause MAP oscillations, while TPR fluctuations appear to be the dominant mediator of LF fluctuations of MAP. CO is not a significant source of these oscillations, and it may only be responsible for dampening them, likely through the baroreflex. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|