Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease
| Autor: | Roland Zahn, Ming Li, David C. Montefiori, Harikrishnan Balachandran, Robert B. White, Birgit Korioth-Schmitz, Norman L. Letvin, Vanessa M. Hirsch, Sarah Pryputniewicz, Melisa D. Rett, Amitinder Kaur, Haili Tang, Jonathan S. Allan, Jörn E. Schmitz, Angela Carville |
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| Rok vydání: | 2010 |
| Předmět: |
CD4-Positive T-Lymphocytes
Time Factors Lymphoid Tissue medicine.medical_treatment Immunology Simian Acquired Immunodeficiency Syndrome Viremia Adaptive Immunity CD8-Positive T-Lymphocytes Biology medicine.disease_cause Biochemistry Lymphocyte Depletion Antibodies Monoclonal Murine-Derived Interferon-gamma Immune system Chlorocebus aethiops medicine Animals Humans Immunobiology Immunosuppression Therapy Immunity Cellular Antibodies Monoclonal Immunosuppression Cell Biology Hematology Simian immunodeficiency virus Antigens CD20 medicine.disease Acquired immune system Antibodies Neutralizing Virology CD4 Lymphocyte Count Immunity Humoral Ki-67 Antigen biology.protein Simian Immunodeficiency Virus African Green Monkey Viral disease Antibody Rituximab Immunologic Memory |
| Zdroj: | Blood. 115:3070-3078 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood-2009-10-245225 |
| Popis: | One of the most puzzling observations in HIV research is the lack of pathogenicity in most nonhuman primate species that are natural hosts of simian immunodeficiency virus (SIV) infection. Despite this, natural hosts experience a level of viremia similar to humans infected with HIV or macaques infected with SIV. To determine the role of adaptive immune responses in viral containment and lack of disease, we delayed the generation of cellular and humoral immune responses by administering anti-CD8– and anti-CD20 lymphocyte–depleting antibodies to sabaeus African green monkeys (Chlorocebus sabaeus) before challenge with SIVsab9315BR. In vivo lymphocyte depletion during primary infection resulted in a brief elevation of viremia but not in disease. Based on the magnitude and timing of SIV-specific CD8+ T-cell responses in the lymphocyte-depleted animals, CD8+ T-cell responses appear to contribute to viral containment in natural hosts. We found no evidence for a contribution of humoral immune responses in viral containment. These studies indicate that natural hosts have developed mechanisms in addition to classic adaptive immune responses to cope with this lentiviral infection. Thus, adaptive immune responses in natural hosts appear to be less critical for viral containment than in HIV infection. |
| Databáze: | OpenAIRE |
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