Influence of low-dose oral contraception on peripheral blood lymphocyte subsets at particular phases of the hormonal cycle
| Autor: | Simon Panzer, L. Auerbach, Johannes C. Huber, Thomas Hafner |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Ethinyl Estradiol-Norgestrel Combination medicine.medical_specialty Lymphocyte media_common.quotation_subject Lymphocytes Null Luteal phase Ethinyl Estradiol Antigens CD Reference Values Desogestrel Internal medicine Ethinylestradiol Follicular phase medicine Humans Prospective Studies Menstrual Cycle Menstrual cycle media_common B-Lymphocytes Dose-Response Relationship Drug business.industry Norgestrel Obstetrics and Gynecology Lymphocyte Subsets Killer Cells Natural Drug Combinations medicine.anatomical_structure Endocrinology Reproductive Medicine Hormonal contraception Peripheral blood lymphocyte Female business Contraceptives Oral medicine.drug |
| Zdroj: | Fertility and Sterility. 78:83-89 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(02)03173-4 |
| Popis: | Objective: To investigate the effects of low-dose oral hormonal contraception on the immune system during certain phases of the hormonal cycle. Design: Prospective, nonrandomized, controlled study. Setting: Academic research setting. Patient(s): Women with regular menstrual cycle using hormonal oral contraception (OC; Cileste®, 250 μg of norgestimat and 35 μg of ethinylestradiol, or Marvelon®, 150 μg of desogestrel and 30 μg of ethinylestradiol) and women not using hormonal or other forms of contraception. Intervention(s): Peripheral blood lymphocyte subsets were determined by flow cytometry on the first day of menstruation (day 1), in the follicular phase (day 8), midcycle (day 15), and in the luteal phase (day 22). Main Outcome Measure(s): Levels of lymphocyte subpopulations. Result(s): Women using OC had significantly higher levels of CD3+ CD8+ cells throughout their pill cycle compared to controls. Furthermore, women taking Cileste® had lower levels of natural killer (NK) cells during their cycle and also women taking Marvelon® but only from days 8–15. Within the pill cycle of Cileste® we observed an increase in CD20+ and CD20+ CD5+ cells from days 1–8. Conclusion(s): Cytotoxic lymphocytes, which are responsible for first-line immune defense, and B cells, which are involved in autoimmune disorders, are affected by OC. |
| Databáze: | OpenAIRE |
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