Clinical and histopathological features resembling those of human focal segmental glomerulosclerosis in a cat with nonimmune-mediated glomerulonephropathy
| Autor: | Takayuki Mineshige, Satoshi Hosaka, Go Sugahara, Kinji Shirota, Junichi Kamiie |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Kidney Glomerulus Fluorescent Antibody Technique Case Report Focal segmental glomerulosclerosis Cat Diseases Kidney urologic and male genital diseases Blood Urea Nitrogen Podocyte Nephrin Glomerulonephritis Microscopy Electron Transmission medicine Animals General Veterinary biology medicine.diagnostic_test Glomerulosclerosis Focal Segmental business.industry Amyloidosis Cat General Medicine medicine.disease veterinary(all) medicine.anatomical_structure Creatinine Cats Podocin biology.protein Renal biopsy Glomerulonephropathy business |
| Zdroj: | BMC Veterinary Research |
| ISSN: | 1746-6148 |
| DOI: | 10.1186/s12917-015-0569-4 |
| Popis: | Background Nonimmune-mediated glomerulonephropathies are rarely reported in domestic animals with the exception of amyloidosis. Here we describe the pathological features and clinical course of a feline with protein-losing nonimmune-mediated glomerulonephropathy characterized by segmental glomerulosclerosis and severe podocyte injury. Case presentation A castrated male Japanese domestic cat aged 3 years and 8 months had hypertension, persistent proteinuria, and azotemia. Microscopic examination of a renal biopsy revealed many glomeruli with adhesion to the Bowman’s capsule and segmental sclerosis. The most characteristic ultrastructural glomerular feature was severe podocyte foot process effacement. No electron-dense deposits were observed. Immunofluorescence revealed no immune deposits, but abnormal expression of nephrin and podocin was detected in the glomeruli. These findings resemble those of human focal segmental glomerulosclerosis. The cat temporarily responded to treatment with angiotensin-converting enzyme inhibitors and prednisolone administration but died of progressive renal failure 32 months after biopsy. Conclusions The cat was diagnosed with nonimmune mediated glomerulonephropathy because of the absence of immune deposits and severe podocyte injury. To our knowledge, this is the first report of nonimmune-mediated glomerulonephropathy in a cat resembling human focal segmental glomerulosclerosis. |
| Databáze: | OpenAIRE |
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