Determination of daunomycin in human plasma and urine by using an interference-free analysis of excitation-emission matrix fluorescence data with second-order calibration
| Autor: | Ru-Qin Yu, A-Lin Xia, Yu-Jie Ding, Hai-Long Wu, Le-Qian Hu, Dong-Mei Fang |
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| Rok vydání: | 2006 |
| Předmět: |
Analyte
Cardiotoxicity Chromatography Antibiotics Antineoplastic Models Statistical Daunorubicin Chemistry Antineoplastic Antibiotic Urine Interference (wave propagation) Fluorescence humanities Chemistry Techniques Analytical Analytical Chemistry Spectrometry Fluorescence Pharmaceutical Preparations Calibration Multivariate Analysis medicine Humans health care economics and organizations Algorithms medicine.drug |
| Zdroj: | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 22(9) |
| ISSN: | 0910-6340 |
| Popis: | Daunorubicin (DNR) is a significant antineoplastic antibiotic, which is usually applied to a chemotherapy of acute lymphatic and myelogenous leukaemia. Unfortunately, cardiotoxicity research in animals has indicated that DNR is cardiotoxic. Therefore, it is important to quantify DNR in biological fluids. A new algorithm, the alternating fitting residue (AFR) method, and the traditional parallel factor analysis (PARAFAC) have been utilized to directly determine DNR in human plasma and urine. These methodologies fully exploit the second-order advantage of the employed three-way fluorescence data, allowing the analyte concentrations to be quantified even in the presence of unknown fluorescent interferents. Furthermore, in contrast to PARAFAC, more satisfactory results were gained with AFR. |
| Databáze: | OpenAIRE |
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