Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure
| Autor: | Irma Edith Carranza-Torres, Rodrigo Lozoya-Martínez, Pilar Carranza-Rosales, Javier Morán-Martínez, Héctor Delgado-Aguirre, Lydia Enith Nava-Rivera, José Omar Zambrano-Ortíz, Nadia Denys Betancourt-Martínez, Nancy Elena Guzmán-Delgado |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Offspring Evolution Molecular biology Science chemistry.chemical_element Physiology 010501 environmental sciences Biology medicine.disease_cause 01 natural sciences Article 03 medical and health sciences Testis medicine Genetics Animals Arsenic 0105 earth and related environmental sciences Multidisciplinary Mutagenicity Tests Reproduction Ovary Environmental Exposure Methylation DNA Methylation Spermatozoa Sperm Phenotype Rats Arsenic contamination of groundwater Disease Models Animal 030104 developmental biology chemistry Maternal Exposure Paternal Exposure DNA methylation Medicine Arsenates Female Genotoxicity DNA Damage |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021) |
| ISSN: | 2045-2322 |
| Popis: | An emerging concern is the influences of early life exposure to environmental toxicants on offspring characteristics in later life. Since recent evidence suggests a transgenerational transference of aberrant phenotypes from exposed-parents to non-exposed offspring related to adult-onset diseases including reproductive phenotype. The transgenerational potential of arsenic a well know genotoxic and epigenetic modifier agent has not been assessed in mammals until now. In this experimental study, we evaluated the transgenerational effects of arsenic in a rat model with chronic exposure to arsenic. Rats chronically exposed to arsenic in drinking water (1 mg As2O3/L) (F0) were mated to produce the arsenic lineage (F1, F2, and F3). The arsenic toxic effects on were evaluated over the four generations by analyzing the DNA methylation percentage, genotoxicity in WBC and physical and reproductive parameters, including sperm quality parameters and histopathological evaluation of the gonads. Chronic exposure to arsenic caused genotoxic damage (F0–F3) different methylation patterns, alterations in physical and reproductive parameters, aberrant morphology in the ovaries (F0 and F1) and testicles (F1–F3), and a decrease in the quality of sperm (F0–F3, except F2). Parental chronic arsenic exposure causes transgenerational genotoxicity and changes in global DNA methylation which might be associated with reproductive defects in rats. Combined with recent studies reveal that disturbances in the early life of an individual can affect the health of later generations. |
| Databáze: | OpenAIRE |
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