Structural organization of the praxis network predicts gesture production: Evidence from healthy subjects and patients with schizophrenia
| Autor: | Marek Kubicki, Roland Wiest, Tim Vanbellingen, René M. Müri, Katharina Stegmayer, Andrea Federspiel, Werner Strik, Sebastian Walther, Sarina Karmacharya, Nikos Makris, Stephan Bohlhalter, Petra V. Viher, Ahmed Abdulkadir, Peter Savadijev |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cognitive Neuroscience Experimental and Cognitive Psychology 610 Medicine & health Corpus callosum Apraxia 050105 experimental psychology 03 medical and health sciences Nonverbal communication 0302 clinical medicine Physical medicine and rehabilitation medicine Humans 0501 psychology and cognitive sciences Association (psychology) Gestures 05 social sciences Fascicle medicine.disease Healthy Volunteers Diffusion Tensor Imaging Neuropsychology and Physiological Psychology Schizophrenia Nerve Net Psychology 030217 neurology & neurosurgery Diffusion MRI Gesture |
| Zdroj: | Viher, Petra; Abdulkadir, Ahmed; Savadijev, Peter; Stegmayer, Katharina; Kubicki, Marek; Makris, Nikos; Karmacharya, Sarina; Federspiel, Andrea; Bohlhalter, Stephan; Vanbellingen, Tim; Müri, René; Wiest, Roland; Strik, Werner; Walther, Sebastian (2020). Structural organization of the praxis network predicts gesture production: Evidence from healthy subjects and patients with schizophrenia. Cortex, 132, pp. 322-333. Elsevier 10.1016/j.cortex.2020.05.023 |
| DOI: | 10.1016/j.cortex.2020.05.023 |
| Popis: | Hand gestures are an integral part of social interactions and communication. Several imaging studies in healthy subjects and lesion studies in patients with apraxia suggest the praxis network for gesture production, involving mainly left inferior frontal, posterior parietal and temporal regions. However, little is known about the structural connectivity underlying gesture production. We recruited 41 healthy participants and 39 patients with schizophrenia. All participants performed a gesture production test, the Test of Upper Limb Apraxia, and underwent diffusion tensor imaging. We hypothesized that gesture production is associated with structural network connectivity as well as with tract integrity. We defined the praxis network as an undirected graph comprised of 13 bilateral regions of interest and derived measures of local and global structural connectivity and tract integrity from Finsler geometry. We found an association of gesture deficit with reduced global and local efficiency of the praxis network. Furthermore, reduced tract integrity, for example in the superior longitudinal fascicle, arcuate fascicle or corpus callosum were related to gesture deficits. Our findings contribute to the understanding of structural correlates of gesture production as they first present diffusion tensor imaging data in a combined sample of healthy subjects and a patient cohort with gestural deficits. |
| Databáze: | OpenAIRE |
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