TOR in the immune system
| Autor: | Ali H. Ellebedy, Rafi Ahmed, Koichi Araki |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
CD4-Positive T-Lymphocytes
TOR Serine-Threonine Kinases Cellular differentiation Cell Differentiation Dendritic Cells Cell Biology Adaptive Immunity Biology Acquired immune system Immunity Innate Article Cell biology TOR signaling Immune system T-Lymphocyte Subsets Animals Humans Cytotoxic T cell Stem cell PI3K/AKT/mTOR pathway Signal Transduction |
| Zdroj: | Current Opinion in Cell Biology. 23:707-715 |
| ISSN: | 0955-0674 |
| Popis: | The target of rapamycin (TOR) is a critical intracellular regulator of the immune system. Recent studies have suggested that immunosuppression by TOR inhibition may be mediated by modulating differentiation of both effector and regulatory CD4 T cell subsets. However, it was paradoxically shown that inhibiting TOR signaling has immunostimulatory effects on the generation of long-lived memory CD8 T cells. Beneficial effects of TOR inhibition have also been observed with dendritic cells and hematopoietic stem cells. This immune modulation may contribute to lifespan extension seen in mice with mTOR inhibition. Here, we review recent findings on TOR modulation of innate and adaptive immune responses, and discuss potential applications of regulating TOR to provide longer and healthier immunity. |
| Databáze: | OpenAIRE |
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