Common bile duct dilatation in drug users with chronic hepatitis C is associated with current methadone use
| Autor: | Stije J. Leopold, Ulrich Beuers, Catharina E. A. Lindenburg, Bart P. X. Grady, Maria Prins, Christine J. Weegink |
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| Přispěvatelé: | Other departments, Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Infectious diseases, Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Side effect Common Bile Duct Diseases Gastroenterology Heroin Interquartile range Internal medicine medicine Opiate Substitution Treatment Humans Pharmacology (medical) Ultrasonography Analysis of Variance Common bile duct medicine.diagnostic_test business.industry Hepatitis C Odds ratio Hepatitis C Chronic Middle Aged medicine.disease Opioid-Related Disorders Psychiatry and Mental health medicine.anatomical_structure Cross-Sectional Studies Abdominal ultrasonography Disease Progression Female business Methadone medicine.drug Dilatation Pathologic |
| Zdroj: | Journal of addiction medicine, 8(1), 53-58. Lippincott Williams and Wilkins |
| ISSN: | 1932-0620 |
| Popis: | Objectives Dilatation of the common bile duct (CBD) can be an ominous sign for malignancy of the pancreatobiliary tract; however, it has also been described as a presumably harmless side effect of opioid use. We investigated the prevalence and determinants of CBD dilatation among drug users receiving methadone maintenance therapy in the Netherlands. Methods A cross-sectional study was conducted in a prospectively studied and well-defined cohort of drug users with chronic hepatitis C virus infection, attending the Public Health Service of Amsterdam, the Netherlands. Patients underwent abdominal ultrasonography as part of pretreatment screening. A multivariable logistic regression model was used to analyze potential demographic and drug use-related determinants of radiological CBD dilatation. Results Between September 2004 and December 2011, 222 hepatitis C virus-infected drug users were evaluated. Dilatation of the CBD was found in 50 of 222 patients (22.5%), with a median diameter of 8.0 mm (interquartile range, 7.0 to 10.0; n = 43). Dilatation was associated with current use of methadone (adjusted odds ratio = 20.50; 95% confidence interval, 2.79 to 2.61 × 10(3)), independent of the current methadone dose, and with age per 10-year increase (adjusted odds ratio = 1.68; 95% confidence interval, 1.06 to 2.71). Regular use of heroin in the 6 months before ultrasonography was not found to be associated with dilatation. Conclusions Dilatation of the CBD is common in drug users under methadone treatment and seems to be a harmless side effect of opioid agonists. |
| Databáze: | OpenAIRE |
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