Immunoscintigraphy of colorectal carcinoma utilizing 111In-labeled monoclonal antibody conjugate CYT-103
| Autor: | T. L. Swan, C. E. Neal, J. G. Katterhagen, R. L. Ellis, M. R. Baker |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer medicine.drug_class Urology Monoclonal antibody Scintigraphy Immunoscintigraphy medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Prospective Studies Radionuclide Imaging Aged Aged 80 and over Radiological and Ultrasound Technology Epithelioma medicine.diagnostic_test business.industry Indium Radioisotopes Gastroenterology Antibodies Monoclonal General Medicine Middle Aged Pentetic Acid medicine.disease Immunoconjugate medicine.anatomical_structure Abdomen Female Radiology Nuclear medicine business Colorectal Neoplasms Tomography X-Ray Computed Oligopeptides |
| Zdroj: | Gastrointestinal radiology. 16(3) |
| ISSN: | 0364-2356 |
| Popis: | Twelve presurgical patients with colorectal carcinoma received a single intravenous infusion of 0.5–20.0 mg of the radiolabeled monoclonal antibody conjugate CYT-103. This product is an immunoconjugate of B72.3 labeled with Indium-111 (111In). Patients underwent preoperative gamma camera imaging and computed tomographic (CT) scanning of the abdomen and pelvis. Fifteen intraabdominal sites of tumor were found at surgery. Monoclonal antibody imaging detected 87% of these lesions, whereas CT of the abdomen and pelvis detected 47%. Monoclonal antibody imaging identified tumor in 27% of the patients in which CT did not identify any sites of tumor. The results of this study indicate that monoclonal antibody imaging using [111In]CYT-103 is useful for the preoperative evaluation of colorectal carcinoma patients and the results are complimentary to CT of the abdomen and the pelvis. |
| Databáze: | OpenAIRE |
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