Nano-selenium and its nanomedicine applications: a critical review
| Autor: | Jarmila Zídková, Qiuming Peng, Magdalena Melčová, Carlos Fernandez, Sylvie Skalickova, Mojmir Baron, Geir Bjørklund, René Kizek, Radka Opatrilova, Bozena Hosnedlova, Branislav Ruttkay-Nedecky, Jiri Sochor, Marta Kepinska |
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| Rok vydání: | 2018 |
| Předmět: |
inorganic chemicals
0301 basic medicine biomedicine Biophysics Administration Oral Pharmaceutical Science chemistry.chemical_element Bioengineering Nanotechnology Review 02 engineering and technology Biomaterials Selenium 03 medical and health sciences Drug Delivery Systems Intestinal mucosa Selenium deficiency Drug Discovery medicine oxidative stress Humans Intestinal Mucosa anticancer effect Organism antimicrobial activity Chemistry Organic Chemistry food and beverages General Medicine 021001 nanoscience & nanotechnology medicine.disease Bioavailability Nanomedicine 030104 developmental biology protective effect drug delivery Drug delivery Nanoparticles Food Additives 0210 nano-technology |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 |
| Popis: | Traditional supplements of selenium generally have a low degree of absorption and increased toxicity. Therefore, it is imperative to develop innovative systems as transporters of selenium compounds, which would raise the bioavailability of this element and allow its controlled release in the organism. Nanoscale selenium has attracted a great interest as a food additive especially in individuals with selenium deficiency, but also as a therapeutic agent without significant side effects in medicine. This review is focused on the incorporation of nanotechnological applications, in particular exploring the possibilities of a more effective way of administration, especially in selenium-deficient organisms. In addition, this review summarizes the survey of knowledge on selenium nanoparticles, their biological effects in the organism, advantages, absorption mechanisms, and nanotechnological applications for peroral administration. |
| Databáze: | OpenAIRE |
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