Aberrant DNA methylation profiling affecting the endometrial receptivity in recurrent implantation failure patients undergoing in vitro fertilization
Autor: | Indira Hinduja, Amruta D S Pathare |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Adult Immunology Fertilization in Vitro Biology Endometrium Chorionic Gonadotropin Andrology 03 medical and health sciences Young Adult 0302 clinical medicine Gene expression medicine Immunology and Allergy Humans Embryo Implantation Treatment Failure Gene 030219 obstetrics & reproductive medicine Obstetrics and Gynecology Promoter Methylation DNA Methylation Gene expression profiling 030104 developmental biology medicine.anatomical_structure Reproductive Medicine CpG site DNA methylation Female Transcriptome |
Zdroj: | American journal of reproductive immunology (New York, N.Y. : 1989)REFERENCES. 83(1) |
ISSN: | 1600-0897 |
Popis: | PROBLEM DNA methylation profile in mid-secretory phase of endometrium is reported to be varied from other phases in natural menstrual cycle. Therefore, we intended to study the impairment in endometrial receptivity by performing whole-genome methylation and gene expression profiling in endometrium of recurrent implantation failure patients (RIF) during IVF under controlled ovarian stimulation (COS). METHOD OF STUDY Endometrial biopsies were collected from IVF-RIF patients (cases, n = 6) and healthy fertile oocyte donors (controls, n = 6) undergoing COS after 6/7th day of human chorionic gonadotropin administration. The whole-genome methylation and gene expression microarray were performed and analysed by GenomeStudio software (P |
Databáze: | OpenAIRE |
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