Activity of Amantadine, Rimantadine, and Ribavirin Against Swine Influenza in Mice and Squirrel Monkeys
| Autor: | George H Scott, Edward L. Stephen, R. F. Berendt |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Time Factors Rimantadine viruses medicine.medical_treatment Pharmacology medicine.disease_cause Virus Mice chemistry.chemical_compound Orthomyxoviridae Infections Ribavirin Amantadine medicine Influenza A virus Animals Pharmacology (medical) Viral shedding Saimiri Chemotherapy biology Haplorhini biology.organism_classification Pharmacology and Therapeutics Virology Infectious Diseases chemistry Female Ribonucleosides medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 13:284-288 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.13.2.284 |
| Popis: | Amantadine, rimantadine, and ribavirin given orally, either prophylactically or therapeutically, reduced mortality and increased the survival time of 3-week-old mice infected with the type A/New Jersey/8/76 (swine) strain of influenza virus. In addition, amantadine and rimantadine, administered therapeutically, increased the rate of virus clearance from lungs of infected mice. Administration of amantadine either before or after virus challenge ameliorated the illness in squirrel monkeys; when administered therapeutically, it appeared to eliminate virus shedding from infected monkeys within hours after therapy was initiated. |
| Databáze: | OpenAIRE |
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