Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors

Autor:	Camille Hauguel, Sarah Ducellier, Olivier Provot, Nada Ibrahim, Diana Lamaa, Coline Balcerowiak, Boris Letribot, Megane Nascimento, Vincent Blanchard, Laurie Askenatzis, Helene Levaique, Jérôme Bignon, Francesco Baschieri, Cyril Bauvais, Guillaume Bollot, Dolor Renko, Alain Deroussent, Bastien Prost, Marie-Catherine Laisne, Sophie Michallet, Laurence Lafanechère, Sébastien Papot, Guillaume Montagnac, Christine Tran, Mouad Alami, Sebastien Apcher, Abdallah Hamze
Rok vydání:	2022
Předmět:	Pharmacology Organic Chemistry Antineoplastic Agents General Medicine Hydroxamic Acids Histone Deacetylases Polymerization Histone Deacetylase Inhibitors Repressor Proteins Tubulin Cell Line Tumor Drug Design Drug Discovery Quinolines Humans Drug Screening Assays Antitumor Cell Proliferation
Zdroj:	European Journal of Medicinal Chemistry. 240:114573
ISSN:	0223-5234
Popis:	A series of quinoline and quinazoline analogs were designed and synthesized as new tubulin polymerization (TP) and histone deacetylases (HDAC) inhibitors. Compounds 12a and 12d showed the best cytotoxicity activities against a panel of human cancer cell lines with an averaged IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7336a68864efb3226acaab439909276 https://doi.org/10.1016/j.ejmech.2022.114573 Zobrazit plný text záznamu Full Text from ScienceDirect