The genetics of human longevity
| Autor: | Daniela Monti, Federica Sevini, Stefano Salvioli, Giovanna De Benedictis, Claudio Franceschi, Graham Pawelec, Miriam Capri, Laura Celani, Silvana Valensin, Efstathios S. Gonos |
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| Přispěvatelé: | Capri M., Salvioli S., Sevini F., Valensin S., Celani L., Monti D., Pawelec G., De Benedictis G., Gonos E.S., Franceschi C. |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Aging
PPARγ medicine.disease_cause Genome Pleiotropy Insulin Insulin-Like Growth Factor I p53 p66shc Aged 80 and over Genetics Mutation General Neuroscience TLR-4 Apolipoprotein Longevity gene Interleukin-10 Multigene Family IL-10 Signal Transduction TGF-β Src Homology 2 Domain-Containing Transforming Protein 1 Longevity Context (language use) Biology General Biochemistry Genetics and Molecular Biology History and Philosophy of Science CETP medicine Humans Epigenetics PON1 Gene Adaptor Proteins Signal Transducing Glycoproteins Genetic association Inflammation IL-6 insulin/IGF-1 Polymorphism Genetic Aryldialkylphosphatase Interleukin-6 Tumor Necrosis Factor-alpha IL-1 cluster Lipid Metabolism Cholesterol Ester Transfer Proteins PPAR gamma Toll-Like Receptor 4 Oxidative Stress Apolipoproteins Shc Signaling Adaptor Proteins TNF-α Tumor Suppressor Protein p53 Carrier Proteins Interleukin-1 Human mitochondrial DNA haplogroup |
| Popis: | Aging is due to a complex interaction of genetic, epigenetic, and environmental factors, but a strong genetic component appears to have an impact on survival to extreme ages. In order to identify "longevity genes" in humans, different strategies are now available. In our laboratory, we performed association studies on a variety of "candidate" polymorphisms in Italian centenarians. Many genes/polymorphisms gave negative results, while others showed a positive association with human longevity and a sometimes-positive association with unsuccessful aging (myocardial infarction, Alzheimer's disease, and type 2 diabetes). Results regarding genes involved in inflammation (IL-1 cluster, IL-6, IL-10, TNF-alpha, TGF-beta, TLR-4, PPARgamma), insulin/IGF-1 signaling pathway and lipid metabolism (apolipoproteins, CETP, PON1), and oxidative stress (p53, p66(shc)) will be described. In addition, a strong role of the interaction between nuclear and mitochondrial genomes (mtDNA haplogroups and the C150T mutation) emerged from our findings. Thus, the genetics of human longevity appears to be quite peculiar in a context where antagonistic pleiotropy can play a major role and genes can have a different biological role at different ages. |
| Databáze: | OpenAIRE |
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