Analyzing the post-contrast attenuation of the esophageal wall on routine contrast-enhanced MDCT examination can improve the diagnostic accuracy in response evaluation of the squamous cell esophageal carcinoma to neoadjuvant chemoradiotherapy in comparison with the esophageal wall thickness
| Autor: | Dusan Saponjski, Milena Cosic-Micev, Marjan Micev, Aleksandra Jankovic, Predrag Pesko, Aleksandra Djuric-Stefanovic, Suzana Stojanovic-Rundic |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Esophageal Neoplasms Urology medicine.medical_treatment media_common.quotation_subject Contrast Media Sensitivity and Specificity 030218 nuclear medicine & medical imaging 03 medical and health sciences Esophagus 0302 clinical medicine Internal medicine Multidetector Computed Tomography medicine Carcinoma Humans Contrast (vision) Radiology Nuclear Medicine and imaging Neoadjuvant therapy Aged Retrospective Studies media_common Tumor Regression Grade Radiological and Ultrasound Technology business.industry Attenuation Gastroenterology Chemoradiotherapy Middle Aged Hepatology medicine.disease Neoadjuvant Therapy 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Histopathology Nuclear medicine business Neoadjuvant chemoradiotherapy |
| Zdroj: | Abdominal Radiology. 44:1722-1733 |
| ISSN: | 2366-0058 2366-004X |
| DOI: | 10.1007/s00261-019-01911-w |
| Popis: | To evaluate the accuracy of the multidetector computed tomography (MDCT) in the response evaluation of the esophageal squamous cell carcinoma (ESCC) to neoadjuvant chemoradiotherapy (nCRT) by analyzing the thickness and post-contrast attenuation of the esophageal wall after the nCRT. Contrast-enhanced (CE)-MDCT examinations in portal venous phase of one hundred patients with locally advanced ESCC who received nCRT and underwent esophageal resection and histopathology assessment of tumor regression grade (TRG) were retrospectively analyzed by measuring the maximal thickness and mean density of the esophageal wall in the segment involved by tumor and visually searching for hyperdense foci within it. Diagnostic performance was evaluated using the ROC analysis. Average attenuation of the esophageal wall had stronger diagnostic performance for predicting pathologic complete regression (pCR) (AUC = 0.994; p |
| Databáze: | OpenAIRE |
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