Accelerated corneal graft rejection in baby rats
| Autor: | Thomas Reinhard, Moritz Berger, Daniel Böhringer, Johannes Schwartzkopff, F. Birnbaum |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
CD4-Positive T-Lymphocytes
Graft Rejection medicine.medical_specialty Neurology Inflammation Adaptive Immunity CD8-Positive T-Lymphocytes Cellular and Molecular Neuroscience Transplantation Immunology Immunity Cornea medicine Animals Postoperative Period Corneal graft rejection Innate immune system business.industry Corneal opacity Age Factors Acquired immune system Immunity Innate Rats Inbred F344 Sensory Systems Rats Surgery Killer Cells Natural Disease Models Animal Ophthalmology medicine.anatomical_structure Rats Inbred Lew Female medicine.symptom business Keratoplasty Penetrating |
| Zdroj: | British Journal of Ophthalmology. 94:1062-1066 |
| ISSN: | 0007-1161 |
| Popis: | Penetrating keratoplasty in infants has a very poor outcome compared to adults. It is of intrinsic interest to gain insight into the still unknown immunological mechanisms of graft failure because any form of uncorrected corneal opacity leads to amblyopia.Allogeneic keratoplasty was performed between Lewis and Fisher rats. The recipients' ages were 10 and 3 weeks, respectively. All experiments were controlled syngeneically. Survival rates were calculated and cellular infiltrates analysed histologically.Median graft survival times were 15 days in old recipients and 9 days in young recipients (p0.01). There were fewer infiltrating cells in the younger rats than in the older ones on the day of rejection. Despite the fact that T cells dominated there were significantly more NK cells in young recipients at all time points after transplantation when compared to old recipients.An animal model has been established that shows similar rejection kinetics as in children, that is corneal graft failure occurs sooner in young rats. Already little infiltration was sufficient to reject a corneal allograft. The dominance of infiltrating NK cells and the vigorous rejection process suggest an involvement of the innate immune system in this process. |
| Databáze: | OpenAIRE |
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