The effect of timolol, betaxolol, and placebo on corneal sensitivity in healthy volunteers
| Autor: | Stanley F. Kulaga, Helmut Hoeh, Robert Tipping, Coleen M. Clineschmidt, Roger Vogel |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male genetic structures Adolescent Administration Topical Timolol Placebo Betaxolol Timolol Ophthalmic Solution Cornea Random Allocation Double-Blind Method Corneal Sensitivity Healthy volunteers Medicine Humans Pharmacology (medical) Pharmacology Betaxolol Ophthalmic Solution business.industry Middle Aged eye diseases Ophthalmology medicine.anatomical_structure Anesthesia Sensory Thresholds Female sense organs business medicine.drug |
| Zdroj: | Journal of ocular pharmacology. 6(2) |
| ISSN: | 8756-3320 |
| Popis: | This study in sixty healthy volunteers investigated the effect of a single drop of either 0.5% timolol ophthalmic solution, 0.5% betaxolol ophthalmic solution, or placebo on corneal sensitivity as measured by the Cochet-Bonnet anesthesiometer. Corneal sensitivity was measured immediately prior to the drop and then 1, 3, 6, 10, 15 and 30 minutes after drop instillation. The timolol treated eyes showed a significant decrease at one minute after instillation. An increase in sensitivity occurred in the placebo group at 15 and 30 minutes. In the eyes treated with betaxolol, a significant reduction in corneal sensitivity was seen at every time point through the 10-minute measurement. |
| Databáze: | OpenAIRE |
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