Star anise extracts modulation of reproductive parameters, fertility potential and DNA fragmentation induced by growth promoter Equigan in rat testes
| Autor: | Kadreya El-Morshedy, Areej Al-Ghadeer, Nora Hamed Al-Shaalan, Thanaa A. El-Masry, Ehab Tousson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Star anises/drug effects lcsh:RS1-441 010501 environmental sciences Biology 01 natural sciences Fertility Agents lcsh:Pharmacy and materia medica 03 medical and health sciences Anabolic steroid/Equigan Sex hormone-binding globulin Internal medicine medicine Testosterone 0105 earth and related environmental sciences Anabolic Agents/pharmacology DNA Fragmentation/drug effects Testis/secretion Fertility Agents Male/analysis Epididymis Sperm 030104 developmental biology medicine.anatomical_structure Endocrinology Illicium verum/drug effects Toxicity biology.protein Sperm Marphometery DNA fragmentation Male/analysis Reproductive Control Agents/pharmacology Spermatogenesis Anabolic steroid Spermatogenesis/drug effects |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences, Vol 54, Iss 1 (2018) Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 1 (2018); e17261 Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 1 (2018); e17261 Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 1 (2018); e17261 Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo (USP) instacron:USP Brazilian Journal of Pharmaceutical Sciences, Volume: 54, Issue: 1, Article number: e17261, Published: 07 JUN 2018 |
| ISSN: | 2175-9790 1984-8250 |
| Popis: | Equigan is an anabolic steroid that has been developed for veterinary use and derived from endogenous sex hormone testosterone that plays a key role in the development of male reproductive tissue as well as in puberty and spermatogenesis. The current study is aimed to investigate the possible prophylactic effect of star anise extracts (SAE) on the toxicity of rat testes, sexual hormones alternations, sperm count, sperm abnormalities and testicular DNA damage by Equigan. Forty adult male rats were equally divided into four groups (1st Control group, 2nd SAE group, 3rd Equigan and 4th Equigan+SAE group). Food and fluid intakes, relative body weight, potassium, chloride, phosphorous, non-progressive and immotile sperms were significantly increased in Equigan group as compared to control group. In contrast; relative testes weight, sodium, magnesium, total calcium, testosterone, FSH, LH, PRL, sperm count, progressive motility, and viability showed a significant decrease in Equigan group as compared to control groups. The relative weight of epididymis, seminal vesicles, prostates and serum calcium ions didn’t change significantly in different studied groups. Co-administration of SAE with Equigan improved the sexual toxicity, electrolyte alternations, sperm count, abnormalities and DNA damage induced by Equigan. |
| Databáze: | OpenAIRE |
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