Schwann cell interactions during the development of the peripheral nervous system
| Autor: | Michael R. Weaver, Emma R. Wilson, M. Laura Feltri, Luciana Romina Frick, Gustavo Della-Flora Nunes |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell type Schwann cell Cell Communication Biology Article Extracellular matrix 03 medical and health sciences Cellular and Molecular Neuroscience Myelin 0302 clinical medicine Developmental Neuroscience Peripheral nerve Peripheral Nervous System medicine Extracellular Axon Axons 030104 developmental biology medicine.anatomical_structure nervous system Peripheral nervous system Schwann Cells Neuroglia Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Dev Neurobiol |
| ISSN: | 1932-846X 1932-8451 |
| Popis: | Schwann cells play a critical role in the development of the peripheral nervous system, establishing important relationships both with the extracellular milieu and other cell types, particularly neurons. In this review, we discuss various Schwann cell interactions integral to the proper establishment, spatial arrangement and function of the peripheral nervous system. We include signals that cascade onto Schwann cells from axons and from the extracellular matrix, bidirectional signals that help to establish the axo-glial relationship and how Schwann cells in turn support the axon. Further, we speculate on how Schwann cell interactions with other components of the developing peripheral nervous system ultimately promote the complete construction of the peripheral nerve. |
| Databáze: | OpenAIRE |
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