The rs1447295 at 8q24 is a risk variant for prostate cancer in Taiwanese men
| Autor: | Marcelo Chen, Yi Ming Arthur Chen, Yen-Hwa Chang, Stone Yang, William J.S. Huang, I-ling Ko, Yu-Chuen Huang |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
Male medicine.medical_specialty Urology Taiwan Disease urologic and male genital diseases Prostate cancer Risk Factors Internal medicine Genotype medicine Humans Allele Risk factor Genotyping Alleles Aged Gynecology business.industry Cancer Prostatic Neoplasms Odds ratio medicine.disease Case-Control Studies business |
| Zdroj: | Urology. 74(3) |
| ISSN: | 1527-9995 |
| Popis: | Objectives To determine the association of a common variant, rs1447295, at the 8q24 region with prostate cancer (PCa) risk in Taiwanese men. Common variants at the 8q24 region have been shown to be associated with PCa risk. The variant rs1447295 has shown the strongest association. Most of the studies have been performed in European and American populations. Methods This case-control study comprised 340 PCa patients and 337 controls. Genotyping was performed for rs14417295 to test for the association between its risk allele and PCa. Its association with disease stage, Gleason score, PSA level, and disease aggressiveness was also determined. Results The A allele of rs1447295 was significantly associated with increased PCa risk (odds ratio=1.49, 95% CI=1.12-1.99). When compared with controls, the risk allele A was more frequent in PCa patients of both stages I+II ( P = .028) and stages III+IV ( P = .023), in patients of all Gleason scores ( P 20 ng/mL ( P = .001), and in patients with aggressive disease ( P = .005). Conclusions This study confirmed that the A allele of rs1447295 is associated with a high risk of PCa in Taiwanese men. |
| Databáze: | OpenAIRE |
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