Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses
Autor: | Emanuela Coutinho Luna, Isadora Silva Luna, Luciana Scotti, Alex France M. Monteiro, Marcus Tullius Scotti, Ricardo Olímpio de Moura, Rodrigo Santos Aquino de Araújo, Kadja Luana Chagas Monteiro, Thiago Mendonça de Aquino, Frederico Fávaro Ribeiro, Francisco Jaime Bezerra Mendonça |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Aging Antiparasitic medicine.drug_class 030231 tropical medicine Review Article Biology Biochemistry 03 medical and health sciences 0302 clinical medicine medicine Oils Volatile Animals African trypanosomiasis lcsh:QH573-671 Close contact Traditional medicine lcsh:Cytology Neglected Diseases Leishmaniasis Cell Biology General Medicine biology.organism_classification medicine.disease 030104 developmental biology Chemical constituents Protozoa Arboviruses |
Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2019 (2019) Oxidative Medicine and Cellular Longevity |
ISSN: | 1942-0994 1942-0900 |
Popis: | The termneglected diseasesrefers to a group of infections caused by various classes of pathogens, including protozoa, viruses, bacteria, and helminths, most often affecting impoverished populations without adequate sanitation living in close contact with infectious vectors and domestic animals. The fact that these diseases were historically not considered priorities for pharmaceutical companies made the available treatments options obsolete, precarious, outdated, and in some cases nonexistent. The use of plants for medicinal, religious, and cosmetic purposes has a history dating back to the emergence of humanity. One of the principal fractions of chemical substances found in plants are essential oils (EOs). EOs consist of a mixture of volatile and hydrophobic secondary metabolites with marked odors, composed primarily of terpenes and phenylpropanoids. They have great commercial value and were widely used in traditional medicine, by phytotherapy practitioners, and in public health services for the treatment of several conditions, including neglected diseases. In addition to the recognized cytoprotective and antioxidative activities of many of these compounds, larvicidal, insecticidal, and antiparasitic activities have been associated with the induction of oxidative stress in parasites, increasing levels of nitric oxide in the infected host, reducing parasite resistance to reactive oxygen species, and increasing lipid peroxidation, ultimately leading to serious damage to cell membranes. The hydrophobicity of these compounds also allows them to cross the membranes of parasites as well as the blood-brain barrier, collaborating in combat at the second stage of several of these infections. Based on these considerations, the aim of this review was to present an update of the potential of EOs, their fractions, and their chemical constituents, against some neglected diseases, including American and African trypanosomiasis, leishmaniasis, and arboviruses, specially dengue. |
Databáze: | OpenAIRE |
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