Antinuclear antibodies in early onset pauciarticular juvenile chronic arthritis (JCA) are associated with HLA-DQB1*0603: a possible JCA-associated human leucocyte antigen haplotype
| Autor: | Taunton R. Southwood, W. E. R. Ollier, L. Holt, A. Farhan, L. Pepper, C. Ryder, D. Carthy, Rachelle Donn, Wendy Thomson |
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| Rok vydání: | 1995 |
| Předmět: |
musculoskeletal diseases
Male endocrine system diseases Anti-nuclear antibody Molecular Sequence Data Human leukocyte antigen Rheumatology Antigen immune system diseases HLA-DQ Antigens Odds Ratio Medicine HLA-DQ beta-Chains Humans Pharmacology (medical) Age of Onset skin and connective tissue diseases Child HLA-D Antigens HLA-DQB1 biology Base Sequence business.industry Haplotype Infant Odds ratio Confidence interval Arthritis Juvenile Logistic Models Antibodies Antinuclear Child Preschool Immunology Chronic Disease biology.protein Female Antibody business |
| Zdroj: | British journal of rheumatology. 34(5) |
| ISSN: | 0263-7103 |
| Popis: | A panel of 43 early onset pauciarticular (EOPA) juvenile chronic arthritis (JCA) patients have been typed for human leucocyte antigens (HLA) DRB1, DPB1, DQA1 alleles, and DQB1*0603 status using molecular-based methods. Increased frequencies of DRB1*08 [odds ratio (OR) 7.7, 95% confidence interval (CI) 2.6-22.3], DRB1*11 (OR 3.1, 95% CI 1.2-8.1), DRB1*1301 (OR 7.7, 95% CI 2.6-22.3), DPB1*0201 (OR 3.5, 95% CI 1.6-8.0), DQA1*0103 (OR 4.4, 95% CI 1.5-13.3), DQA1*0501 (OR 2.9, 95% CI 1.3-6.6), DQA1*0601 (OR 30, 95% CI 3.6-241) and DQB1*0603 (OR 7.3, 95% CI 3.0-17.6) were found in the EOPA-JCA group compared with Caucasoid controls. Stratification of the EOPA-JCA group into antinuclear antibody (ANA) positive (n = 18) and ANA negative (n = 25) individuals revealed that ANA positivity was only associated with DRB1*1301 (OR 4.2, 95% CI 1.0-17.3), DPB1*0201 (OR 4.0, 95% CI 1.0-15.7) and DQB1*0603 (OR 11.5, 95% CI 2.5-53.4). Further analysis of the relative contributions of HLA antigens to ANA status revealed that DQB1*0603 determined the primary HLA effect. No apparent interaction between DQB1*0603 and DRB1*1301 or between DQB1*0603 and DPB1*0201 was found to contribute to the association with ANA. We suggest that those ANA positive individuals with a restricted HLA background, (DQB1*0603 positive), defines a group of EOPA-JCA patients which will be especially valuable in the characterization of the ANA associated with EOPA-JCA. |
| Databáze: | OpenAIRE |
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