Effect of a new anti-ulcer drug, (3-[p-(trans-4-aminomethylcyclohexylcarbonyl)-phenyl] propionic acid hydrochloride, TEI-5103) on prostaglandin (PG) levels in rat gastric mucosa
| Autor: | Toru Takeshita, Kenji Hoshina, Tatsuyuki Naruchi, Shigehiro Takahama, Yorimasa Suwa, Noboru Yamazaki |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Hydrochloride Thromboxane medicine.medical_treatment Radioimmunoassay Prostaglandin Dinoprostone Phospholipases A Guinea pig chemistry.chemical_compound In vivo Internal medicine Gastric mucosa medicine Animals Chromatography High Pressure Liquid Pharmacology Phospholipase A Phenylpropionates Prostaglandins E Rats Inbred Strains Anti-Ulcer Agents Rats Phospholipases A2 medicine.anatomical_structure Endocrinology chemistry Gastric Mucosa Hydroxyprostaglandin Dehydrogenases Prostaglandins lipids (amino acids peptides and proteins) Prostaglandin E |
| Zdroj: | General pharmacology. 19(4) |
| ISSN: | 0306-3623 |
| Popis: | 1. 1. Effect of TEI-5103 on the levels of various prostaglandins (PG's) in rat gastric mucosa was studied by HPLC and RIA methods. 2. 2. When administrated in vivo , TEI-5103 significantly increased the level of prostaglandin E 2 (PGE 2 ) but only slightly increased that of prostaglandin I 2 (PGI 2 ) or thromboxane A 2 (TXA 2 ). 3. 3. In the water-immersion stress model, the PGE 2 level in control animals was increased immediately after stress and then decreased gradually to the initial level. Indomethacin (5 mg/kg, s.c.) sustained a lower PGE 2 level during the experiment, as well as aggravated the lesions. 4. 4. TEI-5103 (400 mg/kg, p.o.) increased the PGE 2 level just before stress, and it resulted in the prevention of lesion formation. 5. 5. TEI-5103 inhibited the activity of 15-OH-PG-dehydrogenase from guinea pig lungs, but did not affect the activity of phospholipase A 2 from porcine pancreas. |
| Databáze: | OpenAIRE |
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