The role of heparins and nano-heparins as therapeutic tool in breast cancer
Autor: | Zoi Piperigkou, Nikos Afratis, Konstantina Karamanou, Achilleas D. Theocharis, Demitrios H. Vynios |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Stromal cell Estrogen receptor Antineoplastic Agents Breast Neoplasms Cell Communication Biochemistry Metastasis Extracellular matrix 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Cell Line Tumor medicine Animals Humans Molecular Biology Cell Proliferation Tumor microenvironment Heparin Chemistry Cancer Cell Biology Heparan sulfate medicine.disease Extracellular Matrix Cell biology Gene Expression Regulation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis Cytokines Intercellular Signaling Peptides and Proteins Female Heparitin Sulfate Stromal Cells Protein Binding Signal Transduction |
Zdroj: | Glycoconjugate Journal. 34:299-307 |
ISSN: | 1573-4986 0282-0080 |
DOI: | 10.1007/s10719-016-9742-7 |
Popis: | Glycosaminoglycans are integral part of the dynamic extracellular matrix (ECM) network that control crucial biochemical and biomechanical signals required for tissue morphogenesis, differentiation, homeostasis and cancer development. Breast cancer cells communicate with stromal ones to modulate ECM mainly through release of soluble effectors during cancer progression. The intracellular cross-talk between cell surface receptors and estrogen receptors is important for the regulation of breast cancer cell properties and production of ECM molecules. In turn, reorganized ECM-cell surface interface modulates signaling cascades, which regulate almost all aspects of breast cell behavior. Heparan sulfate chains present on cell surface and matrix proteoglycans are involved in regulation of breast cancer functions since they are capable of binding numerous matrix molecules, growth factors and inflammatory mediators thus modulating their signaling. In addition to its anticoagulant activity, there is accumulating evidence highlighting various anticancer activities of heparin and nano-heparin derivatives in numerous types of cancer. Importantly, heparin derivatives significantly reduce breast cancer cell proliferation and metastasis in vitro and in vivo models as well as regulates the expression profile of major ECM macromolecules, providing strong evidence for therapeutic targeting. Nano-formulations of the glycosaminoglycan heparin are possibly novel tools for targeting tumor microenvironment. In this review, the role of heparan sulfate/heparin and its nano-formulations in breast cancer biology are presented and discussed in terms of future pharmacological targeting. |
Databáze: | OpenAIRE |
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