Lower Intrafamilial Transmission Rate of Hepatitis B in Patients With Hepatitis D Coinfection: A Data-Mining Approach
| Autor: | Amir Reza Razavi, Saeid Eslami, Seyed Moayed Alavian, Leila Ghalichi, Bashir Hajibeigi, Omid Pournik |
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| Rok vydání: | 2013 |
| Předmět: |
Offspring
computer.software_genre medicine.disease_cause law.invention Machine Learning law medicine Data Mining Medical history Hepatitis B virus Hepatology business.industry virus diseases Hepatitis B medicine.disease Hepatitis D Kowsar Infectious Diseases Transmission (mechanics) Coinfection Data mining Hepatitis B Virus business computer Research Article |
| Zdroj: | Hepatitis Monthly |
| ISSN: | 1735-3408 1735-143X |
| DOI: | 10.5812/hepatmon.7652 |
| Popis: | Background: The presence of an infected family member significantly increases the risk of HBV transmission, but many socio-demographic and viral characteristics of family members affect the transmission rate. Objectives: In this study, we have used data mining techniques to investigate the impact of different variables in intrafamilial transmission of HBV infection. Patients and Methods: demographic information, viral markers, and medical history of 330 patients with chronic hepatitis B and their offspring attending a referral center in Tehran were collected. Data-mining techniques were administered to detect patterns. Results: The overall transmission rate was 15.7% (5.4% and 27.3% for male and female index cases respectively). In female patients, HBe Ag positively affected the transmission rate (49% vs. 23.4%). There was a dominant change in transmission rate of female patients with negative results for Hbe Ag with HDV coinfection, where the transmission rate changed from 25% in patients with negative results for HDV Ab to 5% in those with positive results. In Hbe Ag negative male index cases, the transmission rate was 1.3% in cases with positive results for HDV Ab compared to 7% in those with negative findings. The overall transmission rate was statistically different between patients with positive and negative results for HDV Ab (P = 0.016). Conclusions: There is a minor but consistent pattern change in the presence of HDV infection which reduces familial transmission of HBV, especially in female patients with negative results for HBe Ag. |
| Databáze: | OpenAIRE |
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