Systematic review of the predictors of statin adherence for the primary prevention of cardiovascular disease

Autor: George D. Kitas, Suzanne M M Verstappen, Holly Hope, George M Binkley, Sally A.M. Fenton, Deborah P M Symmons
Rok vydání: 2017
Předmět:
Male
Medical Doctors
Health Care Providers
Myocardial Infarction
Disease
030204 cardiovascular system & hematology
Cardiovascular Medicine
Pathology and Laboratory Medicine
Biochemistry
0302 clinical medicine
Endocrinology
Risk Factors
Medicine and Health Sciences
030212 general & internal medicine
Medical Personnel
education.field_of_study
Multidisciplinary
Drugs
Middle Aged
Lipids
Primary Prevention
Professions
Cholesterol
Manchester Institute for Collaborative Research on Ageing
Cardiovascular Diseases
Medicine
lipids (amino acids
peptides
and proteins)
Female
medicine.medical_specialty
ResearchInstitutes_Networks_Beacons/MICRA
Statin
medicine.drug_class
Endocrine Disorders
Science
Population
Cardiology
Pain
Formal Comment
Medication Adherence
03 medical and health sciences
Signs and Symptoms
Adverse Reactions
Diagnostic Medicine
Internal medicine
Physicians
medicine
Diabetes Mellitus
Humans
cardiovascular diseases
Medical prescription
education
Aged
Polypharmacy
Pharmacology
business.industry
Statins
nutritional and metabolic diseases
Biology and Life Sciences
Myalgia
Health Care
Regimen
Metabolic Disorders
People and Places
Observational study
Population Groupings
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Patient education
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 1, p e0201196 (2019)
Hope, H F, Binkley, G M, Fenton, S, Kitas, G D, Verstappen, S M M & Symmons, D P M 2019, ' Systematic review of the predictors of statin adherence for the primary prevention of cardiovascular disease ', PLoS ONE, vol. 14, no. 1, e0201196 . https://doi.org/10.1371/journal.pone.0201196
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0201196
Popis: IntroductionPrevious research has shown that statin adherence for the primary prevention of CVD is lower compared to secondary prevention populations. Therefore the aim of this systematic review was to review predictors of statin adherence for the primary prevention of CVD.MethodsA systematic search of papers published between Jan 1984 and May 2017 was conducted in PubMed, PsycINFO, EMbase and CINAHL databases. A study was eligible for inclusion if; 1) it was a study of the general population or of patients with familial hypercholesterolemia, hypertension, diabetes or arthritis; 2) statins were prescribed; 3) adherence was defined and measured as the extent to which patients followed their statin regimen during the period of prescription, and 4) it was an original trial or observational study (excluding case reports). A study was subsequently excluded if 1) results were not presented separately for primary prevention; 2) it was a trial of an intervention (for example patient education). Papers were reviewed by two researchers and consensus agreed with a third. A quality assessment (QA) tool was used to formally assess each included article. To evaluate the effect of predictors, data were quantitatively and qualitatively synthesised.ResultsIn total 19 studies met the inclusion criteria and nine were evaluated as high quality using the QA tool. The proportion of patients classed as "adherent" ranged from 17.8% to 79.2%. Potential predictors of statin adherence included traditional risk factors for CVD such as age, being male, diabetes and hypertension. Income associated with adherence more strongly in men than women, and highly educated men were more likely and highly educated women less likely to be adherent. Alcohol misuse and high BMI associated with non-adherence. There was no association between polypharmacy and statin adherence. The evidence base for the effect of other lifestyle factors and health beliefs on statin adherence was limited.ConclusionCurrent evidence suggests that patients with more traditional risk factors for CVD are more likely to be adherent to statins. The implications for future research are discussed.
Databáze: OpenAIRE
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