Role of interleukin-17 in acute myocardial infarction
| Autor: | Adriana Karina Chávez Rueda, Luis Chávez-Sánchez, Mónica Daniela Mora-Ruíz, María Victoria Legorreta-Haquet, Francisco Blanco-Favela |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Immunology Myocardial Infarction Inflammation Models Biological Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system medicine Animals Humans Myocytes Cardiac cardiovascular diseases Myocardial infarction Ventricular remodeling Molecular Biology Receptors Interleukin-17 business.industry Interleukin-17 medicine.disease 030104 developmental biology Cytokine Heart failure Interleukin 17 medicine.symptom business 030215 immunology |
| Zdroj: | Molecular Immunology. 107:71-78 |
| ISSN: | 0161-5890 |
| DOI: | 10.1016/j.molimm.2019.01.008 |
| Popis: | Acute myocardial infarction (AMI) is a leading cause of death worldwide. Myocardial necrosis generates damage signals and triggers an intense inflammatory response. Many cytokines that contribute to repair tissue can also cause adverse left ventricular remodeling and heart failure. Several studies have revealed that interleukin-17 (IL-17) is a cytokine with a potential role in AMI. IL-17 plays an important role in the immune response and affects the production of different inflammatory mediators in several types of cells, involved in the damage or scar process in myocardial tissue. In this review, we will discuss the current knowledge of the role of IL-17 in AMI and the effect of IL-17 in different cells, such as cardiomyocytes, smooth muscle cells and immune system cells, in AMI pathogenesis. |
| Databáze: | OpenAIRE |
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