Increased osteoprotegerin level is associated with impaired cardiovagal modulation in type-2 diabetic patients treated with oral antidiabetic drugs

Autor: Subramaniyam Velkumary, Nivedita Nanda, Jayaprakash Sahoo, G. K. Pal, M. R. Jasmine
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_treatment
Administration
Oral
030204 cardiovascular system & hematology
0302 clinical medicine
Heart rate variability
Type-2 diabetes mellitus
medicine.diagnostic_test
Heart
Vagus Nerve
Middle Aged
Sympathovagal imbalance
Metformin
Up-Regulation
Treatment Outcome
Female
Cardiology and Cardiovascular Medicine
Research Article
Adult
musculoskeletal diseases
medicine.medical_specialty
Cardiometabolic risks
India
030209 endocrinology & metabolism
Risk Assessment
03 medical and health sciences
Osteoprotegerin
Internal medicine
Diabetes mellitus
medicine
Humans
Hypoglycemic Agents
Risk factor
business.industry
Insulin
Cardiometabolic Risk Factors
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
medicine.disease
Sulfonylurea Compounds
Endocrinology
Rate pressure product
Diabetes Mellitus
Type 2
lcsh:RC666-701
Case-Control Studies
business
Lipid profile
Cardiovagal modulation
Biomarkers
Zdroj: BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Cardiovascular Disorders
ISSN: 1471-2261
DOI: 10.1186/s12872-020-01729-1
Popis: Background An increased osteoprotegerin (OPG) level has been reported in both type-2 diabetes mellitus (T2DM) and cardiovascular diease (CVD) that are linked to sympathovagal imbalance (SVI). We explored the link of osteoprotegerin with cardiovagal modulation in T2DM. Methods We assessed fasting serum OPG, high-sensitive C-reactive protein (hsCRP), glucose, insulin and lipid profile in patients having T2DM receiving oral antidiabetic drugs (OAD) (n = 42) compared with age, gender and body composition-matched healthy participants without diabetes (n = 42). Rate pressure product (RPP), spectral indices of heart rate variability (HRV) and body composition were recorded in both the groups. Association of HOMA-IR and OPG with various parameters were assessed. Results Osteoprotegerin, HOMA-IR, hsCRP, coronary lipid risk factor were significantly increased, markers of cardiovagal modulation (TP, SDNN, RMSSD) were considerably decreased, ratio of low-frequency to high-frequency (LH-HF ratio), the indicator of SVI, and RPP, the marker of myocardial work stress were significantly higher in patients with diabetes, suggesting an overall elevated CVD risks in them. HOMA-IR was correlated with RMSSD, lipid risk factors and OPG. Rise in OPG was correlated with decreased cardiovagal modulation in patients with diabetes. There was significant contribution of OPG in decreasing TP, suggesting impaired cardiovagal modulation. Conclusion T2DM patients receiving OAD had higher cardiometabolic risks compared to age, gender and body composition-matched healthy individuals. Increased level of OPG is linked to decreased cardiovagal modulation in T2DM patients.
Databáze: OpenAIRE
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