Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample
| Autor: | Pedro Mario Pan, Gisele Gus Manfro, Sintia Iole Belangero, Jair de Jesus Mari, Elisa Brietzke, Ary Gadelha, Márcia Kauer-Sant'Anna, Rodrigo Grassi-Oliveira, Euripedes Constantino Miguel, Giovanni Abrahão Salum, André Zugman, Graccielle R. Cunha, Rodrigo A. Bressan, Laura Stertz, Adiel C. Rios, Elson Asevedo, Mateus Luz Levandowski, Rodrigo B. Mansur |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent Developmental Disabilities Population Long Term Adverse Effects CBCL Child Behavior Disorders Thiobarbituric Acid Reactive Substances Cohort Studies 03 medical and health sciences 0302 clinical medicine Pregnancy Malondialdehyde Developmental and Educational Psychology Child and adolescent psychiatry medicine TBARS Humans Child education Child Behavior Checklist education.field_of_study Psychopathology business.industry Mental Disorders General Medicine Checklist 030227 psychiatry Oxidative Stress Psychiatry and Mental health Mental Health Socioeconomic Factors Pediatrics Perinatology and Child Health Female Lipid Peroxidation Psychiatric interview business Brazil 030217 neurology & neurosurgery Cohort study |
| Zdroj: | European Child & Adolescent Psychiatry. 26:521-529 |
| ISSN: | 1435-165X 1018-8827 |
| DOI: | 10.1007/s00787-016-0914-6 |
| Popis: | Replicated evidence indicates that perinatal complications are associated with increased markers of oxidative stress and with mental health problems in children. However, there are fewer reports on the impact of perinatal complications in later phases of development. We aimed to investigate the estimated effects of perinatal complications on levels of lipid peroxidation and on psychopathology in children and adolescents. The study is part of the High Risk Cohort Study for Psychiatric Disorders; the population was composed by 554 students, 6-14 years of age. Serum levels of malondialdehyde, a product of lipid peroxidation, were measured by the TBARS method. A household interview with parents and caregivers was conducted and included inquiries about perinatal history, the Child Behavior Checklist (CBCL), and parent's evaluation, using the Mini International Psychiatric Interview (MINI). We created a cumulative risk index, conceptualized as each individual's cumulative exposure to perinatal complications. Results indicate that perinatal complications were associated with higher levels of TBARS. After adjusting for age, gender, socio-economic status, CBCL total problems score, parental psychopathology, and childhood maltreatment, children exposed to 3 or more perinatal complications had an 26.9% (95% CI 9.9%, 46.6%) increase in TBARS levels, relative to the unexposed group. Exploratory mediation analysis indicated that TBARS levels partially mediated the association between perinatal complications and externalizing problems. In conclusion, an adverse intrauterine and/or early life environment, as proxied by the cumulative exposure to perinatal complications, was independently associated with higher levels of lipid peroxidation in children and adolescents. |
| Databáze: | OpenAIRE |
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