Streptococcal infection in childhood Henoch-Schönlein purpura: a 5-year retrospective study from a single tertiary medical center in China, 2015–2019
| Autor: | Man Man Niu, Hui Hui Liu, Rui Xue Li, Zhen Qiu, Jin Wei Ruan, Peng Hu, Wei Xia Chen, Guo Zhen Fan, Qi Jiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Abdominal pain China Henoch-Schonlein purpura IgA Vasculitis Biopsy Kidney Glomerulus Arthritis Diseases of the musculoskeletal system medicine.disease_cause Pediatrics RJ1-570 Immunoglobulin a 03 medical and health sciences 0302 clinical medicine Rheumatology Recurrence Internal medicine Streptococcal Infections medicine Immunology and Allergy Humans 030212 general & internal medicine Child Correlation of Data Retrospective Studies 030203 arthritis & rheumatology medicine.diagnostic_test Streptococcus business.industry Renal pathology Retrospective cohort study medicine.disease Henoch-Schönlein purpura RC925-935 Pediatrics Perinatology and Child Health Female Kidney Diseases Renal biopsy medicine.symptom business Research Article |
| Zdroj: | Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-11 (2021) Pediatric Rheumatology Online Journal |
| ISSN: | 1546-0096 |
| Popis: | Background The present study focuses on the associations of streptococcal infection with the clinical phenotypes, relapse/recurrence and renal involvement in Henoch-Schönlein purpura (HSP) children. Methods Two thousand seventy-four Chinese children with HSP were recruited from January 2015 to December 2019. Patients’ histories associated with HSP onset were obtained by interviews and questionnaires. Laboratory data of urine tests, blood sample and infectious agents were collected. Renal biopsy was performed by the percutaneous technique. Results (1) Streptococcal infection was identified in 393 (18.9%) HSP patients, and served as the most frequent infectious trigger. (2) Among the 393 cases with streptococcal infection, 43.0% of them had arthritis/arthralgia, 32.1% had abdominal pain and 29.3% had renal involvement. (3) 26.1% of HSP patients relapsed or recurred more than 1 time within a 5-year observational period, and the relapse/recurrence rate in streptococcal infectious group was subjected to a 0.4-fold decrease as compared with the non-infectious group. (4) No significant differences in renal pathological damage were identified among the streptococcal infectious group, the other infectious group and the non-infectious group. Conclusions Streptococcal infection is the most frequent trigger for childhood HSP and does not aggravate renal pathological damage; the possible elimination of streptococcal infection helps relieve the relapse/recurrence of HSP. |
| Databáze: | OpenAIRE |
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