Response of pancreatic immunoreactive somatostatin to arginine
| Autor: | G. S. Patton, Roger H Unger, E. Ipp, Wylie Vale, R. E. Dobbs, Lelio Orci |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
endocrine system
medicine.medical_specialty Arginine medicine.medical_treatment In Vitro Techniques Glucagon General Biochemistry Genetics and Molecular Biology Islets of Langerhans Dogs Internal medicine Insulin Secretion medicine Animals Insulin General Pharmacology Toxicology and Pharmaceutics geography Delta cell geography.geographical_feature_category Chemistry Pancreatic islets Glucagon secretion General Medicine Islet Stimulation Chemical Somatostatin Endocrinology medicine.anatomical_structure Secretory Rate hormones hormone substitutes and hormone antagonists |
| Zdroj: | Life sciences. 19(12) |
| ISSN: | 0024-3205 |
| Popis: | Perfusion of isolated dog pancreases with arginine (20 mM) was associated with a prompt and sustained increase in immunoreactive somatostatin (IRS) in the venous effluent while insulin and glucagon rose promptly but soon receded from their peak levels. These results are compatible with a postulated feedback relationship between somatostatin-, glucagon-, and perhaps insulin-secreting cells of the islets in which somatostatin, stimulated by local glucagon, restrains glucagon secretion and perhaps glucagon-mediated insulin release as well. The demonstration that D-cells of the pancreatic islets contain immunoreactive somatostatin (1, 2, 3) which is probably biologically active (4), and are situated topographically between the A-cells and B-cells in the heterocellular region of the islet (5) has suggested a functional role for these components of the islet of Langerhans (6). In view of the inhibitory action of somatostatin upon both insulin and glucagon secretion (7, 8, 9), it was postulated that the D-cell might serve to restrain glucagon and/or insulin secretion (6). We have since reported that the release of IRS from the isolated dog pancreas increases promptly during the perfusion of high concentrations of glucagon whereas high concentrations of insulin do not appear to stimulate IRS release (10). In this study we examine the effect of perfusion with arginine, a potent stimulus of both glucagon and insulin secretion, upon pancreatic IRS release. |
| Databáze: | OpenAIRE |
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