Erythropoetin receptor expression in the human diabetic retina
| Autor: | Vinit B. Mahajan, Shaival S. Shah, Stephen H. Tsang |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty genetic structures Receptor expression Short Report lcsh:Medicine General Biochemistry Genetics and Molecular Biology Pathogenesis 03 medical and health sciences 0302 clinical medicine medicine Outer nuclear layer lcsh:Science (General) lcsh:QH301-705.5 030304 developmental biology Medicine(all) 0303 health sciences Retina business.industry Biochemistry Genetics and Molecular Biology(all) lcsh:R food and beverages General Medicine Diabetic retinopathy medicine.disease Erythropoietin receptor Ophthalmology medicine.anatomical_structure Retinal ganglion cell lcsh:Biology (General) Erythropoietin embryonic structures 030221 ophthalmology & optometry Cancer research sense organs business medicine.drug lcsh:Q1-390 |
| Zdroj: | BMC Research Notes, Vol 2, Iss 1, p 234 (2009) BMC Research Notes |
| DOI: | 10.7916/d80000g9 |
| Popis: | Background Recent evidence suggests erythropoietin (EPO) and the erythropoietin receptor (EPOR) may play a direct role in the pathogenesis of diabetic retinopathy. Better characterization of the EPO-EPOR signaling system in the ischemic retina may offer a new therapeutic modality for ischemic ophthalmic diseases. This study was performed to identify EPOR mRNA expression in the human diabetic eye. Findings EPOR antisense RNA probes were validated on human pancreas tissue. In the normal eye, EPOR was expressed in the retinal ganglion cell layer. Minimal expression was observed in the inner and outer nuclear layer. Under conditions of diabetic retinopathy, EPOR expression shifted to photoreceptor cells. Increased expression was also observed in the peripheral retina. Conclusion EPOR expression may be a biomarker or contribute to disease mechanisms in diabetic retinopathy. |
| Databáze: | OpenAIRE |
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