Beta-lactam resistance among Enterobacteriaceae in Cambodia: The four-year itch
| Autor: | Nop Puthea, Meng Soda, Sébastien Boyer, Yannick Caron, Arnaud Tarantola, Alexandra Kerleguer, R. Chheang |
|---|---|
| Přispěvatelé: | Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Microbiology (medical) medicine.drug_class Klebsiella pneumoniae [SDV]Life Sciences [q-bio] 030106 microbiology Population Antibiotics Microbial Sensitivity Tests beta-Lactams medicine.disease_cause Antimicrobial resistance beta-Lactam Resistance beta-Lactamases lcsh:Infectious and parasitic diseases Microbiology Extended-spectrum-beta-lactamases 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Enterobacteriaceae Disk Diffusion Antimicrobial Tests [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases medicine Escherichia coli Humans lcsh:RC109-216 030212 general & internal medicine education Escherichia coli Infections Etest Retrospective Studies 2. Zero hunger education.field_of_study Public health issue biology Enterobacteriaceae Infections General Medicine biology.organism_classification Anti-Bacterial Agents 3. Good health Multiple drug resistance Infectious Diseases Cambodia |
| Zdroj: | International Journal of Infectious Diseases International Journal of Infectious Diseases, Elsevier, 2018, 66, pp.74-79. ⟨10.1016/j.ijid.2017.10.025⟩ International Journal of Infectious Diseases, Vol 66, Iss C, Pp 74-79 (2018) International Journal of Infectious Diseases, Elsevier, 2018, 66, pp.74-79. 〈10.1016/j.ijid.2017.10.025〉 |
| ISSN: | 1201-9712 1878-3511 |
| DOI: | 10.1016/j.ijid.2017.10.025⟩ |
| Popis: | International audience; Although antibiotics are too often used inappropriately in Cambodia, published data on antimicrobial resistance in this country are scarce. Epidemic dissemination and the transfer of resistance genes to other bacterial species put the population at risk. The aim of this study was to evaluate the frequency and characteristics of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) isolated in consecutive samples tested at Institut Pasteur du Cambodge over a 4-year period (2012-2015). Antimicrobial susceptibility testing was performed by disk diffusion on agar technique and the results were read automatically using an OSIRIS system. The Etest was used to determine minimum inhibitory concentrations (MIC) for some resistance phenotypes. The strain most commonly identified was Escherichia coli (63.9%). The proportion of ESBL-E increased gradually over the study period, from 23.8% to 38.4%. ESBL was detected in 42.7% of the E. coli strains and 33.7% of all Klebsiella pneumoniae isolated. The proportion of ESBL-producing E. coli increased significantly from 28.9% in 2012 to 48.2% in 2015, while the increase for K. pneumoniae remained non-significant. Multidrug resistance was high in this Cambodian series, with some strains displaying resistance to all antibiotics available in the country. There is currently no established system for the surveillance of antimicrobial resistance in Cambodia. Collecting samples from clinical settings throughout the country is critical to assess the impact of antimicrobial drug use in patients in Cambodia and in the Mekong Region. |
| Databáze: | OpenAIRE |
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