Anaplastic thyroid carcinoma in Denmark 1996-2012: A national prospective study of 219 patients

Autor: Gitte Bjørn Hvilsom, Christoffer Holst Hahn, Katalin Kiss, Henrik Baymler Pedersen, Christian Godballe, Stefano Christian Londero, Marie Louise Jespersen, Giedrius Lelkaitis, Sten Schytte, Peer Christiansen, Stine Rosenkilde Larsen
Rok vydání: 2017
Předmět:
Adult
Male
Cancer Research
medicine.medical_specialty
Survival
Databases
Factual
Epidemiology
Denmark
Thyroid Neoplasms/epidemiology
030209 endocrinology & metabolism
Thyroid Carcinoma
Anaplastic
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Internal medicine
Lymphatic Metastasis/pathology
Medicine
Humans
Prospective Studies
Thyroid Neoplasms
Stage (cooking)
Prospective study
Prospective cohort study
Thyroid cancer
Aged
Aged
80 and over
business.industry
Clinical outcome
Incidence (epidemiology)
Incidence
Anaplastic thyroid carcinoma
Cancer
Middle Aged
medicine.disease
Prognosis
Denmark/epidemiology
Thyroid Carcinoma
Anaplastic/epidemiology
Oncology
Fast track cancer programs
Thyroid epidemiology
030220 oncology & carcinogenesis
Lymphatic Metastasis
Cohort
Multivariate Analysis
Female
Fast track
business
Cohort study
Zdroj: Hvilsom, G B, Londero, S C, Hahn, C H, Schytte, S, Pedersen, H B, Christiansen, P, Kiss, K, Larsen, S R, Jespersen, M L, Lelkaitis, G & Godballe, C 2018, ' Anaplastic thyroid carcinoma in Denmark 1996-2012 : A national prospective study of 219 patients ', Cancer epidemiology, vol. 53, pp. 65-71 . https://doi.org/10.1016/j.canep.2018.01.011
Hvilsom, G B, Londero, S C, Hahn, C H, Schytte, S, Pedersen, H B, Christiansen, P, Kiss, K, Larsen, S R, Jespersen, M L, Lelkaitis, G & Godballe, C 2018, ' Anaplastic thyroid carcinoma in Denmark 1996-2012 : A national prospective study of 219 patients ', Cancer Epidemiology, vol. 53, pp. 65-71 . https://doi.org/10.1016/j.canep.2018.01.011
ISSN: 1877-783X
Popis: BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients.METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014.RESULTS: We found the median age in the 7th decade, the majority of patients being women presenting with a growing mass at the neck, diagnosed with stage T4b disease. At diagnosis, 56% of the patients had lymph node metastasis and 38% distant metastasis. We observed one- and five-year survival of 20.7% and 11.0%, respectively. Both univariate and multivariate analyses showed age (above 73.6 years), respiratory impairment, T4b stage, and distant metastasis at diagnosis to be significant prognostic factors. Further, introduction of a national fast track cancer program increased survival nearly two-fold.CONCLUSION: As new information, our study adds "respiratory impairment at diagnosis" and "introduction of a national fast track cancer program" to the list of already established prognostic indicators for ATC.
Databáze: OpenAIRE
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