The bradykinin system in stress and anxiety in humans and mice
| Autor: | William McEntegart, Ari Rouhiainen, Kalevi Trontti, Petri Hyytiä, Iiris Hovatta, Marie Mennesson, Suvi Saarnio, Tessa Sipilä, Lea Martta Urpa, Zuzanna Misiewicz, Natalia Kulesskaya, Ewa Sokolowska |
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| Přispěvatelé: | Molecular and Integrative Biosciences Research Programme, SLEEPWELL Research Program, Medicum, Institute for Molecular Medicine Finland, Department of Psychology and Logopedics, Neuroscience Center, STEMM - Stem Cells and Metabolism Research Program, Helsinki In Vivo Animal Imaging Platform (HAIP), Department of Pharmacology, Iiris Hovatta / Principal Investigator, Genetics, Mind and Matter |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
DISORDER
0301 basic medicine Male Receptor Bradykinin B2 Kallikrein-Kinin System Physiology lcsh:Medicine Anxiety Receptor Bradykinin B1 chemistry.chemical_compound Mice 0302 clinical medicine Brown adipose tissue Bradykinin B2 Receptor Antagonists Chronic stress Receptor lcsh:Science GENE-EXPRESSION Multidisciplinary Brain Anxiety Disorders Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Up-Regulation medicine.anatomical_structure Behavioural genetics Female medicine.symptom Adult medicine.medical_specialty medicine.drug_class Bradykinin DORSAL PERIAQUEDUCTAL GRAY ADMINISTERED BRADYKININ Naphthalenes Anxiolytic Polymorphism Single Nucleotide Article 03 medical and health sciences Organophosphorus Compounds Downregulation and upregulation Species Specificity Internal medicine medicine Animals Humans Bradykinin receptor ANTAGONIST business.industry Kininogens lcsh:R 3112 Neurosciences Bradykinin B1 Receptor Antagonists ASSOCIATION ANALYSIS Disease Models Animal 030104 developmental biology Endocrinology B-2 RECEPTOR chemistry RAT lcsh:Q Gene expression business 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-55947-5 |
| Popis: | Pharmacological research in mice and human genetic analyses suggest that the kallikrein-kinin system (KKS) may regulate anxiety. We examined the role of the KKS in anxiety and stress in both species. In human genetic association analysis, variants in genes for the bradykinin precursor (KNG1) and the bradykinin receptors (BDKRB1 and BDKRB2) were associated with anxiety disorders (p Pgc1a and the bradykinin precursor gene Kng2 was upregulated after cold stress. Our data suggests that the bradykinin system modulates a variety of stress responses through B2 receptor-mediated effects, but systemic antagonists of the B2 receptor were not anxiolytic in mice. Genetic variants in the bradykinin receptor genes may predispose to anxiety disorders in humans by affecting their function. |
| Databáze: | OpenAIRE |
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