Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants
| Autor: | Marta Di Carlo, Antonella Sgarbossa, Daniela Giacomazza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Antioxidant
Amyloid Coumaric Acids medicine.medical_treatment Central nervous system lcsh:TX341-641 Review Pharmacology medicine.disease_cause Alzheimer Disease medicine oxidative stress Humans Senile plaques Nutrition and Dietetics Amyloid beta-Peptides nanotechnology Chemistry Neurotoxicity apoptosis Alzheimer's disease Free radical scavenger medicine.disease Ferula medicine.anatomical_structure antioxidants Biochemistry lcsh:Nutrition. Foods and food supply Alzheimer’s disease fibrillogenesis Intracellular Oxidative stress Food Science |
| Zdroj: | Nutrients Nutrients, Vol 7, Iss 7, Pp 5764-5782 (2015) Nutrients 7 (2015): 5764–5782. doi:10.3390/nu7075246 info:cnr-pdr/source/autori:Sgarbossa A.; Giacomazza D.; Di Carlo M./titolo:Ferulic acid: A hope for Alzheimer's disease therapy from plants/doi:10.3390%2Fnu7075246/rivista:Nutrients/anno:2015/pagina_da:5764/pagina_a:5782/intervallo_pagine:5764–5782/volume:7 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu7075246 |
| Popis: | Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the deposition of extracellular amyloid-beta peptide (Aβ) and intracellular neurofibrillar tangles, associated with loss of neurons in the brain and consequent learning and memory deficits. Aβ is the major component of the senile plaques and is believed to play a central role in the development and progress of AD both in oligomer and fibril forms. Inhibition of the formation of Aβ fibrils as well as the destabilization of preformed Aβ in the Central Nervous System (CNS) would be an attractive therapeutic target for the treatment of AD. Moreover, a large number of studies indicate that oxidative stress and mitochondrial dysfunction may play an important role in AD and their suppression or reduction via antioxidant use could be a promising preventive or therapeutic intervention for AD patients. Many antioxidant compounds have been demonstrated to protect the brain from Aβ neurotoxicity. Ferulic acid (FA) is an antioxidant naturally present in plant cell walls with anti-inflammatory activities and it is able to act as a free radical scavenger. Here we present the role of FA as inhibitor or disaggregating agent of amyloid structures as well as its effects on biological models. |
| Databáze: | OpenAIRE |
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