Macular microvascular changes after intravitreal bevacizumab injection in diabetic macular edema
| Autor: | Saber Molaei, Maryam Ashraf Khorasani, Khalil Ghasemi Falavarjani, Abbas Habibi, Shahriar Ghasemizadeh, David Sarraf, Pasha Anvari, Reza Mirshahi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures Bevacizumab Diabetic macular edema Macular Edema 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Ophthalmology Diabetes Mellitus medicine Humans Prospective Studies Fluorescein Angiography Intravitreal bevacizumab Prospective cohort study Aged Plexus Diabetic Retinopathy medicine.diagnostic_test business.industry Retinal Vessels General Medicine Blood flow Middle Aged medicine.disease Fluorescein angiography eye diseases Intravitreal Injections 030221 ophthalmology & optometry sense organs business Tomography Optical Coherence medicine.drug |
| Zdroj: | Canadian Journal of Ophthalmology. 56:57-65 |
| ISSN: | 0008-4182 |
| DOI: | 10.1016/j.jcjo.2020.07.004 |
| Popis: | Objective To evaluate the changes in retinal capillary plexus and the choriocapillaris after a single intravitreal injection of bevacizumab in eyes with diabetic macular edema using optical coherence tomography angiography (OCTA). Design Prospective interventional case series. Participants Patients having diabetes with centre-involving diabetic macular edema. Methods In this prospective interventional case series, eyes with centre-involving diabetic macular edema were enrolled. Vascular density (VD), vascular diameter index (VDI), vascular length density (VLD), foveal avascular zone (FAZ) area, and foveal density (FD)-300 were measured using en face OCTA images before and 1 month after administration of intravitreal bevacizumab. VD and VDI measurements were performed in the superficial capillary plexus (SCP) and deep retinal capillary plexus (DCP) and in the choriocapillaris. Additionally, capillary nonperfusion area (CNPA) was detected automatically based on vessel distance map in 4 concentric rings around the foveal centre. The segmentation error was manually corrected, and the measurements were performed by 2 expert graders. Results Twenty-three eyes of 19 patients with a mean age of 62.76 ± 6.88 years were included. There were no significant changes in the FAZ area, FD-300, or in the VD of the foveal and parafoveal SCP and DCP. Also, VLD and VDI of the SCP and DCP remained unchanged. The change in the CNPA was not statistically significant. The VD of choriocapillaris increased significantly after injections (p = 0.005). Conclusions FAZ area and VD of the retinal capillary plexus remained stable in the short-term period after intravitreal bevacizumab. In addition, the choriocapillaris blood flow improved after bevacizumab injection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect