Characterization of the spontaneous diabetes obesity syndrome in mature male CBA/Ca mice
| Autor: | P.V. Taberner, D.M. Connelly |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Mice Inbred Strains Type 2 diabetes Biology Hyperphagia Toxicology Biochemistry Impaired glucose tolerance Behavioral Neuroscience Mice Inbred strain Internal medicine Diabetes mellitus medicine Diabetes Mellitus Animals Insulin Obesity Biological Psychiatry Pancreatic hormone Triglycerides Pharmacology Incidence (epidemiology) Age Factors nutritional and metabolic diseases medicine.disease Disease Models Animal Endocrinology Diabetes Mellitus Type 1 Female |
| Zdroj: | Pharmacology, biochemistry, and behavior. 34(2) |
| ISSN: | 0091-3057 |
| Popis: | A spontaneous maturity onset diabetes obesity syndrome occurs in a small proportion (10-20%) of male CBA/Ca mice. Inbreeding can increase the incidence to 80%. It occurs at 12-16 weeks of age, and is characterized by hyperphagia, obesity, hyperglycaemia, hypertriglyceridaemia, hyperinsulinaemia, and an impaired glucose tolerance. The mice are also resistant to exogenous insulin. Female mice remain normal except for a slight increase in serum insulin. The male obese diabetic mice have a normal life expectancy. It is proposed that CBA/Ca mice can provide examples of a useful model for investigating the aetiology of type 2 diabetes and obesity, and the effectiveness of antidiabetic and antiobesity drugs. |
| Databáze: | OpenAIRE |
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